Regular proton pump inhibitor use and incident dementia: population-based cohort study

To examine the association between regular use of proton pump inhibitors and the risk of incident dementia, including dementia subtypes, and whether the association differs between APOE genotypes. Based on a prospective analysis of data from the UK Biobank, 501,002 individuals (female, 54.4%) aged b...

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Bibliographic Details
Published in:	BMC medicine Vol. 20; no. 1; pp. 271 - 11
Main Authors:	Zhang, Peidong, Li, Zhihao, Chen, Peiliang, Zhang, Ao, Zeng, Yu, Zhang, Xiru, Huang, Qingmei, Liu, Dan, Qi, Songtao, Mao, Chen
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 01-09-2022 BioMed Central BMC
Subjects:	Adult Aged Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's disease Amyloid-β APOE Apolipoprotein E Apolipoprotein E4 - drug effects Cohort analysis Cohort Studies Comorbidity Complications and side effects Dementia Dementia disorders Dementia, Vascular - epidemiology Development and progression Female Gastroesophageal reflux Genotype & phenotype Genotypes Health risk assessment Heterozygotes Humans Inhibitors Metabolism Middle Aged Neurodegenerative diseases Observational studies Population Population studies Population-based studies Proton pump inhibitors Proton Pump Inhibitors - adverse effects Protons Risk Factors Statistical models Vascular dementia United Kingdom United Kingdom > UK Proton pump inhibitors APOE Amyloid-β Alzheimer’s disease Dementia
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