Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats

• Published in: Experimental Animals Vol. 55; no. 2; pp. 91 - 95
• Main Authors: TACHIBANA, Masayoshi, LU, Lingmin, HIAI, Hiroshi, TAMURA, Atsushi, MATSUSHIMA, Yoshibumi, SHISA, Hayase
• Format: Journal Article
• Language: English
• Published: Japan Japanese Association for Laboratory Animal Science 01-04-2006
• Subjects: Animals; Chromosome Mapping; Diethylstilbestrol - toxicity; diethystilbesterol; Endocrine Disruptors - toxicity; LEXF and FXLE rat; Male; Organ Size - drug effects; Pituitary Gland - drug effects; Prolactin - blood; QTL; Rats; Rats, Inbred Strains - genetics; recombinant inbred strain; Recombination, Genetic; testis; Testis - drug effects
• ISSN: 1341-1357; 1881-7122
• DOI: 10.1538/expanim.55.91

Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.