Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles

microRNAs (miRs), a novel class of small non-coding RNAs, are involved in cell proliferation, differentiation, development, and death. In this study, we found that miR-221 translocation by microvesicles (MVs) plays an important role in cardioprotection mediated by GATA-4 overexpressed mesenchymal st...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 8; p. e73304
Main Authors:	Yu, Bin, Gong, Min, Wang, Yigang, Millard, Ronald W, Pasha, Zeeshan, Yang, Yueting, Ashraf, Muhammad, Xu, Meifeng
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 28-08-2013 Public Library of Science (PLoS)
Subjects:	Angiogenesis Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biology Bone marrow Cardiomyocytes Caspase Caspase-3 CD63 antigen CD9 antigen Cell Hypoxia - genetics Cell proliferation Cloning Coculture Techniques Conditioning Electron microscopy GATA-4 gene GATA4 Transcription Factor - genetics GATA4 Transcription Factor - metabolism Heart Heart Ventricles - cytology Heart Ventricles - metabolism Hsp70 protein Hypoxia Ischemia L-Lactate dehydrogenase Laboratory animals Lactate dehydrogenase Lactic acid Male Medicine Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Neonates p53 Protein Pathology Penicillin Rats Rats, Sprague-Dawley Rodents Stem cell transplantation Stem cells Studies Transfection Translocation Transplants & implants Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ventricle Viruses United States > US Ohio
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