Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and PPi. Although dUTP is a normal intermediate in DNA synthesis, its accumulation and misincorporation into DNA is lethal. Importantly, uracil misincorporation is a mechanism of cytotoxicity induced by...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 37; no. 1; pp. 78 - 95
Main Authors:	Wilson, Peter M, Fazzone, William, LaBonte, Melissa J, Lenz, Heinz-Josef, Ladner, Robert D
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-01-2009 Oxford Publishing Limited (England)
Subjects:	Animals Antineoplastic Agents - toxicity Binding Sites Cell Line Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - physiology Deoxyuracil Nucleotides - biosynthesis DNA Damage Down-Regulation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Regulation, Chromatin and Epigenetics Humans Organoplatinum Compounds - toxicity Promoter Regions, Genetic Pyrophosphatases - genetics Pyrophosphatases - metabolism Repressor Proteins - biosynthesis Repressor Proteins - genetics Repressor Proteins - metabolism Sp1 Transcription Factor - physiology Thymidylate Synthase - antagonists & inhibitors Transcription Factors - metabolism Transcription, Genetic Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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