Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino...

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Published in:FEBS letters Vol. 203; no. 1; pp. 25 - 30
Main Authors: Seino, S., Welsh, M., Bell, G.I., Chan, S.J., Steiner, D.F.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 14-07-1986
Elsevier
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
cDNA
Cloning, Molecular
DNA - genetics
Fundamental and applied biological sciences. Psychology
genes
Genes. Genome
Glucagon - genetics
Guinea Pigs
Molecular and cellular biology
Molecular genetics
Mutation
nucleotide sequence
preproglucagon
Proglucagon
Protein Precursors - genetics
Sequence Homology, Nucleic Acid
Vertebrata
Mammalia
Guinea pig
Complementary DNA
Glucagon
Gene
Rodentia
Primary structure
Mutation
Prohormone
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Abstract A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species. Glucagon Evolution Hystricomorph cDNA Glycogenolytic hormone
AbstractList Glucagon Evolution Hystricomorph cDNA Glycogenolytic hormone
A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred.
A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species. Glucagon Evolution Hystricomorph cDNA Glycogenolytic hormone
A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.
Author Bell, G.I.
Welsh, M.
Steiner, D.F.
Seino, S.
Chan, S.J.
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  surname: Welsh
  fullname: Welsh, M.
  organization: Department of Biochemistry & Molecular Biology, The University of Chicago, Chicago, IL, USA
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  surname: Bell
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  organization: Chiron Corporation, Emeryville, CA 94608, USA
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  surname: Chan
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  givenname: D.F.
  surname: Steiner
  fullname: Steiner, D.F.
  organization: The Howard Hughes Medical Institute, The University of Chicago, 920 E, 58th Street, Chicago, IL 60637, USA
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FEBS Letters 203 (1986) 1873-3468 © 2015 Federation of European Biochemical Societies
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Issue 1
Keywords Vertebrata
Mammalia
Guinea pig
Complementary DNA
Glucagon
Gene
Rodentia
Primary structure
Mutation
Prohormone
Language English
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Snippet A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly...
Glucagon Evolution Hystricomorph cDNA Glycogenolytic hormone
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pascalfrancis
wiley
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StartPage 25
SubjectTerms Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
cDNA
Cloning, Molecular
DNA - genetics
Fundamental and applied biological sciences. Psychology
genes
Genes. Genome
Glucagon - genetics
Guinea Pigs
Molecular and cellular biology
Molecular genetics
Mutation
nucleotide sequence
preproglucagon
Proglucagon
Protein Precursors - genetics
Sequence Homology, Nucleic Acid
Title Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence
URI https://dx.doi.org/10.1016/0014-5793(86)81429-6
https://onlinelibrary.wiley.com/doi/abs/10.1016%2F0014-5793%2886%2981429-6
https://www.ncbi.nlm.nih.gov/pubmed/3755107
https://search.proquest.com/docview/14538442
https://search.proquest.com/docview/76900604
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