Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence

• Published in: FEBS letters Vol. 203; no. 1; pp. 25 - 30
• Main Authors: Seino, S., Welsh, M., Bell, G.I., Chan, S.J., Steiner, D.F.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14-07-1986; Elsevier
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; cDNA; Cloning, Molecular; DNA - genetics; Fundamental and applied biological sciences. Psychology; genes; Genes. Genome; Glucagon - genetics; Guinea Pigs; Molecular and cellular biology; Molecular genetics; Mutation; nucleotide sequence; preproglucagon; Proglucagon; Protein Precursors - genetics; Sequence Homology, Nucleic Acid; Vertebrata; Mammalia; Guinea pig; Complementary DNA; Glucagon; Gene; Rodentia; Primary structure; Mutation; Prohormone
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(86)81429-6

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.
Glucagon
Evolution
Hystricomorph
cDNA
Glycogenolytic hormone