Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice

Animal models for neurodevelopmental disorders (NDD) generally rely on a single genetic mutation on a fixed genetic background. Recent human genetic studies however indicate that a clinical diagnosis with ASDAutism Spectrum Disorder (ASD) is almost always associated with multiple genetic fore- and b...

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Bibliographic Details
Published in:	Molecular autism Vol. 9; no. 1; p. 63
Main Authors:	Molenhuis, Remco T, Bruining, Hilgo, Brandt, Myrna J V, van Soldt, Petra E, Abu-Toamih Atamni, Hanifa J, Burbach, J Peter H, Iraqi, Fuad A, Mott, Richard F, Kas, Martien J H
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 13-12-2018 BioMed Central BMC
Subjects:	Animal models Animals Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - genetics Behavioral neuroscience Diagnosis Gene mutation Genetic aspects Genetic reference population Genetics, Behavioral - methods Genetics, Behavioral - standards Genome-Wide Association Study - methods Genome-Wide Association Study - standards Male Mice Mice, Inbred C57BL Multifactorial Inheritance Mutation Neurodevelopmental disorders Pervasive developmental disorders Quantitative genetics Quantitative Trait Loci Reference Standards Risk factors Rodents Studies Quantitative genetics Autism Animal models Genetic reference population Neurodevelopmental disorders Behavioral neuroscience Repetitive behavior Histamine 3 receptor
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