Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis

The Indian subcontinent is the only region where arsenic contamination of drinking water coexists with widespread resistance to antimonial drugs that are used to treat the parasitic disease visceral leishmaniasis. We have previously proposed that selection for parasite resistance within visceral lei...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 49; pp. 19932 - 19937
Main Authors:	Perry, Meghan R., Wyllie, Susan, Raab, Andrea, Feldmann, Joerg, Fairlamb, Alan H.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 03-12-2013 NATIONAL ACADEMY OF SCIENCES National Acad Sciences
Series:	From the Cover
Subjects:	Amastigotes Animals Antimony Antimony Sodium Gluconate Antiprotozoal Agents - metabolism Arsenic Arsenic - toxicity Biological Sciences Cell Line Contamination Drinking water Drinking Water - analysis Drug resistance Drug Resistance - drug effects Environmental Exposure - adverse effects India Leishmania - drug effects Leishmania donovani Leishmaniasis, Visceral - drug therapy Liver Macrophages - drug effects Mass Screening Mass Spectrometry Medical treatment failures Mice Mice, Inbred BALB C Parasites Potable water Rodents Spleen Visceral leishmaniasis Water Pollutants, Chemical - toxicity India India, Bihar drug resistance treatment failure sodium antimony gluconate environmental pollution
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