AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of androgen/neurosteroid, potentiates glioblastoma to acquire resistance through attenuating DNA damage. Androgen receptor (AR) act...

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Bibliographic Details
Published in:	Redox biology Vol. 30; p. 101413
Main Authors:	Chen, Tzu-Chi, Chuang, Jian-Ying, Ko, Chiung-Yuan, Kao, Tzu-Jen, Yang, Pei-Yu, Yu, Chun-Hui, Liu, Ming-Sheng, Hu, Siou-Lian, Tsai, Yu-Ting, Chan, Hardy, Chang, Wen-Chang, Hsu, Tsung-I.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-02-2020 Elsevier
Subjects:	ALZ003 Animals Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Cell Proliferation - drug effects Curcumin - analogs & derivatives Drug Resistance, Neoplasm - drug effects F-Box Proteins - metabolism Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism GPX4 Humans Male Mice Phospholipid Hydroperoxide Glutathione Peroxidase - genetics Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Primary Cell Culture Proteolysis Receptors, Androgen - metabolism Research Paper Tumor Cells, Cultured Tumor Microenvironment - drug effects Ubiquitination Xenograft Model Antitumor Assays AR GPX4 ALZ003 Glioblastoma
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