肺癌图表演化见证转化性研究发展
肺癌从传统化疗到分子靶向,再到如今免疫治疗的转变,转化性研究发挥着无可替代的作用,其中图表演化更是见证一次次重大变迁,从＂森林图＂到＂生存曲线图＂,＂瀑布图＂,＂蜘蛛图＂再到最近的＂时间线区域面积图＂,纵向展示了肺癌治疗从群体逐渐向个体深入细化的理念和演进过程。尽管目前最新的免疫治疗炙手可热,但其研究结果并没有达到预期理想,同时传统的治疗手段仍然存在局限性,需要更深入探索。本文将从图表演化角度论述肺癌转化性研究的发展历程,剖析部分失败的外科临床研究,以期对未来肺癌治疗及图表演化有所启发。...
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| Published in: | 中国肺癌杂志 Vol. 19; no. 6; pp. 403 - 408 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | Chinese |
| Published: |
510080广州，广东省肺癌研究所，广东省人民医院肿瘤外科
2016
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | 肺癌从传统化疗到分子靶向,再到如今免疫治疗的转变,转化性研究发挥着无可替代的作用,其中图表演化更是见证一次次重大变迁,从＂森林图＂到＂生存曲线图＂,＂瀑布图＂,＂蜘蛛图＂再到最近的＂时间线区域面积图＂,纵向展示了肺癌治疗从群体逐渐向个体深入细化的理念和演进过程。尽管目前最新的免疫治疗炙手可热,但其研究结果并没有达到预期理想,同时传统的治疗手段仍然存在局限性,需要更深入探索。本文将从图表演化角度论述肺癌转化性研究的发展历程,剖析部分失败的外科临床研究,以期对未来肺癌治疗及图表演化有所启发。 |
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| Bibliography: | Lung cancer treatment has altered from conventional chemotherapy to targeted treatment, which now has been turned to the immunotherapy. Translational research has played an irreplaceable role during this progression which graphic evolution has witnessed. The evolution has gone through forest plot, KM-curve, waterfall plot, spider plot and timelinearea, showing us the refining concept and gradual process of lung cancer treatment undergoing from community towards individual. Even though the latest immunotherapy is getting increasingly hot, the result isn＇t quite expected. Meanwhile, the limitations of conventional treatment still exist which require further research. This article will primarily illustrate the development of translational research of lung cancer via the aspect of curve evolution and analysis some abortive clinical trials in lung cancer surgery for inspiring the next graphic style and lung cancer treatment. Chao ZHANG,Wenzhao ZHONG（Department of Surgical Oncology, Guangdong Lung Cancer Institute, |
| ISSN: | 1009-3419 1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2016.06.21 |