Systems biology of innate immunity

• Published in: Cellular immunology Vol. 244; no. 2; pp. 105 - 109
• Main Authors: Tegnér, Jesper, Nilsson, Roland, Bajic, Vladimir B., Björkegren, Johan, Ravasi, Timothy
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Netherlands Elsevier Inc 01-12-2006
• Subjects: Dynamics; Genome; Humans; Immunity, Innate - genetics; Immunity, Innate - immunology; Innate immunity; Lipopolysaccharides - immunology; Macrophages; Macrophages - immunology; Medicin och hälsovetenskap; Models, Immunological; Networks; Oligonucleotide Array Sequence Analysis; Protein-protein interactions; Regulatory circuits; Systems Biology; TECHNOLOGY; TEKNIKVETENSKAP; Transcription, Genetic; Transcriptional regulation; Networks; Protein–protein interactions; Systems biology; Dynamics; Regulatory circuits; Innate immunity; Transcriptional regulation; Genome; Macrophages
• ISSN: 0008-8749; 1090-2163; 1090-2163
• DOI: 10.1016/j.cellimm.2007.01.010

Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes. These endeavors, collectively referred to as systems biology establish a paradigm by which to systematically interrogate, model, and iteratively refine our knowledge of the regulatory events within a cell. Here, we present a new systems approach, integrating DNA and transcript expression information, specifically designed to identify transcriptional networks governing the macrophage immune response to lipopolysaccharide (LPS). Using this approach, we are not only able to infer a global macrophage transcriptional network, but also time-specific sub-networks that are dynamically active across the LPS response. We believe that our system biological approach could be useful for identifying other complex networks mediating immunological responses.