The Phosphodiesterase Inhibitor Rolipram Delivered after a Spinal Cord Lesion Promotes Axonal Regeneration and Functional Recovery

Although there is no spontaneous regeneration of mammalian spinal axons after injury, they can be enticed to grow if cAMP is elevated in the neuronal cell bodies before the spinal axons are cut. Prophylactic injection of cAMP, however, is useless as therapy for spinal injuries. We now show that the...

Full description

Saved in:

Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 23; pp. 8786 - 8790
Main Authors:	Nikulina, Elena, Tidwell, J. Lille, Dai, Hai Ning, Bregman, Barbara S., Filbin, Marie T., Goodman, Corey S.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 08-06-2004 National Acad Sciences
Subjects:	Animals Axons Axons - drug effects Axons - pathology Axons - physiology Biological Sciences Central Nervous System Agents - administration & dosage Central Nervous System Agents - pharmacology CHO cells Cyclic AMP - metabolism Drug therapy Enzymes Fetal Tissue Transplantation Forelimbs Lesions Myelin Nerve Regeneration - drug effects Neurology Neurons Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - pharmacology Physical trauma Rats Rats, Long-Evans Rolipram - administration & dosage Rolipram - pharmacology Spinal cord Spinal Cord - transplantation Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology Vehicles
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!