The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin has been reported to have a beneficial effect on reducing the new onset of diabetes as well as lowering plasma lipids. Because pravastatin is a water-soluble organic anion, it cannot easily penetrate the lipid bilayer of the c...

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Published in:	DRUG METABOLISM AND PHARMACOKINETICS Vol. 25; no. 3; pp. 274 - 282
Main Authors:	Abe, Michiaki, Toyohara, Takafumi, Ishii, Akiko, Suzuki, Takehiro, Noguchi, Naoya, Akiyama, Yasutoshi, Shiwaku, Hiromi O., Nakagomi-Hagihara, Rie, Zheng, Guodong, Shibata, Eisuke, Souma, Tomokazu, Shindo, Tomohiko, Shima, Hirohito, Takeuchi, Yoichi, Mishima, Eikan, Tanemoto, Masayuki, Terasaki, Tetsuya, Onogawa, Tohru, Unno, Michiaki, Ito, Sadayoshi, Takasawa, Shin, Abe, Takaaki
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-01-2010 Japanese Society for the Study of Xenobiotics
Subjects:	Adiponectin - blood adipose Animals Biological Transport - drug effects Cell Line, Tumor diabetes Diabetes Mellitus - drug therapy disease endobiotics HMG-CoA reductase inhibitors Hydroxymethylglutaryl CoA Reductases Immunohistochemistry insulin Insulin - agonists Insulin - metabolism Insulin Secretion islet Islets of Langerhans - cytology Islets of Langerhans - drug effects Male Mice Mice, Inbred Strains Models, Animal OATP organ Organic Anion Transporters, Sodium-Independent - analysis Organic Anion Transporters, Sodium-Independent - metabolism Pancreas - cytology Pancreas - drug effects Pravastatin - pharmacokinetics Pravastatin - pharmacology Rats Rifampin - pharmacology SLC transporters SLCO (SLC21) Sulfobromophthalein - pharmacology xenobiotics organ endobiotics disease insulin HMG-CoA reductase inhibitors xenobiotics SLC transporters adipose OATP islet diabetes SLCO (SLC21)
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