Neural tube defect genes and maternal diabetes during pregnancy

BACKGROUND: Maternal diabetes during pregnancy is a well‐known teratogen that increases the risk for birth defects, such as neural tube defects (NTDs). We have previously shown that maternal diabetes profoundly affects gene expression in the developing embryo, in particular a suite of known NTD gene...

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Bibliographic Details
Published in:	Birth defects research. A Clinical and molecular teratology Vol. 88; no. 8; pp. 601 - 611
Main Authors:	Salbaum, J. Michael, Kappen, Claudia
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-08-2010
Subjects:	Animal models Animals Congenital defects Diabetes mellitus Diabetes, Gestational - genetics Embryogenesis Embryos epigenetic modifications epigenetics Female Gene Expression Gene Expression Profiling Gene Expression Regulation, Developmental Gene regulation Genetic Variation Humans incomplete penetrance Kidney - physiology Mice Neural tube defects Neural Tube Defects - genetics Placenta - physiology Pregnancy signaling pathways Teratogenicity Teratogens Therapeutic applications Transcription Transcription Factors - genetics Transcription, Genetic variability
Online Access:	Get full text
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