Generation of functional hemangioblasts from human embryonic stem cells

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages. Here we describe an efficient and reproducible method for generating large numbers of these bipotential progenitor...

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Bibliographic Details
Published in:	Nature methods Vol. 4; no. 6; pp. 501 - 509
Main Authors:	Lanza, Robert, Lu, Shi-Jiang, Feng, Qiang, Caballero, Sergio, Chen, Yu, Moore, Malcolm A S, Grant, Maria B
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01-06-2007
Subjects:	Animals Blood circulation disorders Blood Vessels - cytology Care and treatment Cell Differentiation Diabetes Mellitus, Type 2 Diabetic Retinopathy - therapy Embryonic stem cells Embryonic Stem Cells - cytology Hematopoietic Stem Cells - cytology Hindlimb - blood supply Humans Injection Ischemia - pathology Ischemia - therapy Methods Mice Mice, Inbred NOD Mice, SCID Mortality Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - therapy Physiological aspects Rats Reperfusion Injury - therapy Stem Cell Transplantation Stem cells Transgenic animals Transplants & implants United States
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