A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Disruption of histone acetylation patterns is a common feature of cancer cells, but very little is known about its genetic basis. We have identified truncating mutations in one of the primary human histone deacetylases, HDAC2, in sporadic carcinomas with microsatellite instability and in tumors aris...

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Bibliographic Details
Published in:	Nature genetics Vol. 38; no. 5; pp. 566 - 569
Main Authors:	Esteller, Manel, Ropero, Santiago, Fraga, Mario F, Ballestar, Esteban, Hamelin, Richard, Yamamoto, Hiroyuki, Boix-Chornet, Manuel, Caballero, Rosalia, Alaminos, Miguel, Setien, Fernando, Paz, Maria F, Herranz, Michel, Palacios, Jose, Arango, Diego, Orntoft, Torben F, Aaltonen, Lauri A, Schwartz, Simó
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group 01-05-2006
Subjects:	Amino Acid Sequence Antineoplastic Agents - therapeutic use Apoptosis Biological and medical sciences Cancer Cell Cycle Colorectal carcinoma Drug Resistance, Neoplasm - genetics Electrophoresis, Capillary Enzymatic activity Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Gene expression Genetics of eukaryotes. Biological and molecular evolution Histone Deacetylase 2 Histone Deacetylase Inhibitors Histone Deacetylases - chemistry Histone Deacetylases - genetics Humans Inhibitor drugs Molecular Sequence Data Mutation Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Repressor Proteins - antagonists & inhibitors Repressor Proteins - chemistry Repressor Proteins - genetics RNA, Small Interfering Human Resistance Inhibition Mutation Malignant tumor Histone
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