Natural products - antifungal agents derived from plants

• Published in: Journal of asian natural products research Vol. 11; no. 7; pp. 621 - 638
• Main Authors: Arif, Tasleem, Bhosale, J.D., Kumar, Naresh, Mandal, T.K., Bendre, R.S., Lavekar, G.S., Dabur, Rajesh
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Group 01-07-2009; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Acquired immune deficiency syndrome; Alkaloids; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; antifungal; Antifungal activity; Antifungal agents; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Bacteria; bioactive metabolites; Biological and medical sciences; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Cancer; Drug development; Drug discovery; Flavonoids; Fungal infections; General pharmacology; Humans; Immunocompromised hosts; Infection; Medical sciences; Metabolites; Molecular Structure; natural products; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; R&D; Research & development; Reviews; Saponins; Secondary metabolites; Tannic acid; tannins; Tannins - chemistry; Tannins - isolation & purification; Tannins - pharmacology; Steroid; Lectin; Peptides; Coumarine derivatives; Review; Flavonoid; Medicinal plant; Saponin; Alkaloid; Antifungal agent; Tannin; Glycoside; Essential oil; saponins; Terpenoid; Pharmacognosy; Quinone; Glycoprotein; alkaloids; Lactone; Natural compound; Biological activity; Protein; antifungal; Polypeptide; Plant origin; Triterpene; tannins; bioactive metabolites; flavonoids
• ISSN: 1028-6020; 1477-2213
• DOI: 10.1080/10286020902942350

A new spectrum of human fungal infections is increasing due to increased cancer, AIDS, and immunocompromised patients. The increased use of antifungal agents also resulted in the development of resistance to the present drugs. It makes necessary to discover new classes of antifungal compounds to cure fungal infections. Plants are rich source of bioactive secondary metabolites of wide variety such as tannins, terpenoids, saponins, alkaloids, flavonoids, and other compounds, reported to have in vitro antifungal properties. Since the plant kingdom provides a useful source of lead compounds of novel structure, a wide-scale investigation of species from the tropics has been considered. Therefore, the research on natural products and compounds derived from natural products has accelerated in recent years due to their importance in drug discovery. A series of molecules with antifungal activity against different strains of fungus have been found in plants, which are of great importance to humans. These molecules may be used directly or considered as a precursor for developing better molecules. This review attempts to summarize the current status of important antifungal compounds from plants.