Evidence of Autocrine Modulation of Macrophage Nitric Oxide Synthase by α-Melanocyte-Stimulating Hormone

α-Melanocyte-stimulating hormone (α-MSH) is a potent inhibitory agent in all major forms of inflammation. To identify a potential mechanism of antiinflammatory action of α-MSH, we tested its effects on production of nitric oxide (NO), believed to be a mediator common to all forms of inflammation. We...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 17; pp. 8016 - 8020
Main Authors:	Star, Robert A., Rajora, Nilum, Huang, Jijing, Stock, Renee C., Catania, Anna, Lipton, J. M.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 15-08-1995 National Acad Sciences National Academy of Sciences
Subjects:	alpha-MSH - pharmacology Amino Acid Oxidoreductases - biosynthesis Amino Acid Oxidoreductases - metabolism Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Arginine - analogs & derivatives Arginine - pharmacology Base Sequence Cell Line Complementary DNA Cytokines DNA Primers Endothelial cells Gene Expression - drug effects Hormones Humans Inflammation Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Medical research Messenger RNA Mice Models, Biological Molecular Sequence Data Nitration Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Nitrites omega-N-Methylarginine Polymerase Chain Reaction Pro-Opiomelanocortin - biosynthesis Receptors Receptors, Corticotropin - biosynthesis Receptors, Melanocortin Recombinant Proteins RNA, Messenger - analysis RNA, Messenger - biosynthesis Salmonella typhi
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