Depletion-Activated Calcium Current is Inhibited by Protein Kinase in RBL-2H3 Cells

Whole-cell patch-clamp recordings and single-cell Ca2+measurements were used to study the control of Ca2+entry through the Ca2+release-activated Ca2+influx pathway (ICRAC) in rat basophilic leukemia cells. When intracellular inositol 1,4,5-trisphosphate (InsP3)-sensitive stores were depleted by dial...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 17; pp. 7907 - 7911
Main Authors:	Parekh, Anant B., Penner, Reinhold
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 15-08-1995 National Acad Sciences National Academy of Sciences
Subjects:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Adenosine-5'-(N-ethylcarboxamide) Agonists Alkaloids - pharmacology Anatomy & physiology Animals Antigens Calcium Calcium - metabolism Calcium Channels - physiology Cell Line Cells Dialysis Egtazic Acid - pharmacology Fura-2 - analogs & derivatives Homeostasis Indoles - pharmacology Inositol 1,4,5-Trisphosphate - pharmacology Kinetics Leukemia Leukemia, Basophilic, Acute Maleimides - pharmacology Mast cells Patch-Clamp Techniques Phosphorylation Physiological regulation Pipettes Protein Kinase C - antagonists & inhibitors Protein Kinases - metabolism Proteins Rats Receptors Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - physiology Rodents Secretion Staurosporine Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured
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