Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease

J. Neurochem. (2010) 113, 978-989. The glial glutamate transporter EAAT2 (excitatory amino acid transporter 2) is the major mediator of glutamate clearance that terminates glutamate-mediated neurotransmission. Loss of EAAT2 and associated glutamate uptake function has been reported in the brains of...

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Published in:	Journal of neurochemistry Vol. 113; no. 4; pp. 978 - 989
Main Authors:	Tian, Guilian, Kong, Qiongman, Lai, Liching, Ray-Chaudhury, Abhik, Lin, Chien-liang G
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-05-2010 Blackwell Publishing Ltd Wiley-Blackwell
Subjects:	Adult and adolescent clinical studies Aged Alzheimer disease Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Astrocytes - metabolism Biochemistry Biological and medical sciences Brain - metabolism Brain - physiopathology Brain Chemistry - physiology Cholesterol Cholesterol - metabolism Cholesterol 24-Hydroxylase cholesterol 24S-hydroxylase Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Excitatory Amino Acid Transporter 2 - metabolism excitotoxicity glutamate transporter EAAT2 Glutamic Acid - metabolism Humans lipid raft microdomain Medical sciences Membrane Microdomains - metabolism Neurology Neurotransmitters Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Steroid Hydroxylases - metabolism Up-Regulation - physiology Oxidative stress Alzheimer disease Neuroglia Central nervous system Lipids Hyperlipoproteinemia lipid raft microdomain Clearance Lipoprotein Encephalon Degenerative disease Degeneration Dyslipemia excitotoxicity Alzheimer's disease Nervous system diseases GLT-1 glutamate transporter cholesterol 24S-hydroxylase Metabolic diseases Glutamate Uptake Cholesterol Cerebral disorder Hypercholesterolemia Neuron Central nervous system disease Plasma membrane Excitatory aminoacid Neurotransmitter Disruption Neurotransmission glutamate transporter EAAT2
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