TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

• Published in: Egyptian Journal of Medical Human Genetics Vol. 22; no. 1; pp. 83 - 4
• Main Authors: Peralta, Estela Morales, Rosales, Yaíma Zúñiga, Mesa, Teresa Collazo, González, Elvia Nelmi Santos, Pérez, Yadira Hernández, de los Ángeles González Torres, María, Balbuena, Hilda Roblejo
• Format: Journal Article
• Language: English
• Published: Cairo Springer 30-11-2021; Springer Nature B.V; Springer Berlin Heidelberg; SpringerOpen
• Subjects: Alleles; Coronaviruses; Correspondence; COVID-19; Cuba; Ethylenediaminetetraacetic acid; Gene polymorphism; Genes; Genetic polymorphism; Genetic polymorphisms; Health aspects; Lead poisoning; Medical genetics; Medical research; Medicine, Experimental; Patients; Polymorphism; Receptor; Vitamin D; Cuba
• ISSN: 1110-8630; 2090-2441
• DOI: 10.1186/s43042-021-00206-4

Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243-17.842], even severe [OR = 1.200, 95% CI: 0.217-6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.