Inhibition of Cyclin-Dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat

Increasing evidence suggests that cyclin-dependent kinases participate in neuronal death induced by multiple stresses in vitro. However, their role in cell death paradigms in vivo is not well characterized. Accordingly, the authors examined whether cyclin-dependent kinase inhibition resulted in func...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism Vol. 22; no. 2; pp. 171 - 182
Main Authors:	Wang, Fuhu, Corbett, Dale, Osuga, Hitoshi, Osuga, Sachiko, Ikeda, Joh-E, Slack, Ruth S., Hogan, Matthew J., Hakim, Antoine M., Park, David S.
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-02-2002 Lippincott Williams & Wilkins Sage Publications Ltd
Subjects:	Animals Behavior, Animal - drug effects Biological and medical sciences Body Temperature - drug effects Brain Ischemia - physiopathology Brain Ischemia - psychology Cell Survival - drug effects Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Hippocampus - physiopathology Male Maze Learning - physiology Medical sciences Neurology Neurons - physiology Neuroprotective Agents - pharmacology Piperidines - pharmacology Rats Rats, Wistar Retinoblastoma Protein - metabolism Swimming Time Factors Vascular diseases and vascular malformations of the nervous system Neuroprotection Delayed neuronal death Morris water maze Global cerebral ischemia Cyclin-dependent kinases Apoptosis Nervous system diseases Pathophysiology Rat Enzyme Transferases Rodentia Cyclin Cardiovascular disease Neuroprotective agent Cerebral disorder Vascular disease Vertebrata Experimental disease Mammalia Ischemia Kinase Animal Central nervous system disease Cerebrovascular disease Brain (vertebrata)
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