Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193

Four novel antitumor antibiotics (PD 114,759, PD 115,028, PD 119,707 and PD 119,193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values o...

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 38; no. 10; p. 1337
Main Authors:	Tunac, J B, Graham, B D, Mamber, S W, Dobson, W E, Lenzini, M D
Format:	Journal Article
Language:	English
Published:	Japan 01-01-1985
Subjects:	Actinomycetales - metabolism Animals Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - pharmacology Biological Products Fermentation Leukemia, Experimental - drug therapy Mice Mice, Inbred Strains Microbial Sensitivity Tests
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Summary:	Four novel antitumor antibiotics (PD 114,759, PD 115,028, PD 119,707 and PD 119,193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values of less than 0.006 ng/ml against several bacteria and ID50 values of 0.003 approximately 0.107 ng/ml against L1210 leukemia cells in vitro. Antitumor activities vs. P388 leukemia in vivo were observed at doses of 0.313, 0.40, and 0.5 micrograms/kg (daily X 5) for PD 119,707, PD 115,028, and PD 114,759, respectively.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.38.1337