Homozygous Deletions within Human Chromosome Band 9p21 in Melanoma

Genetic studies have implicated the early involvement of a gene on chromosome arm 9p in the development of cutaneous melanoma. We have performed loss-of-heterozygosity studies to confirm these original findings and identify the most frequently rearranged or deleted region of 9p. Eight markers were a...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 89; no. 21; pp. 10557 - 10561
Main Authors:	Fountain, Jane W., Karayiorgou, Maria, Ernstoff, Marc S., Kirkwood, John M., Vlock, Daniel R., Titus-Ernstoff, Linda, Bouchard, Bridgitte, Vijayasaradhi, Setaluri, Houghton, Alan N., Lahti, Jill, Kidd, Vincent J., Housman, David E., Dracopoli, Nicholas C.
Format:	Journal Article
Language:	English
Published:	Washington, DC National Academy of Sciences of the United States of America 01-11-1992 National Acad Sciences National Academy of Sciences
Subjects:	Alleles Base Sequence beta-N-Acetylglucosaminylglycopeptide beta-1,4-Galactosyltransferase - genetics Biological and medical sciences Cell Line Cell lines chromosome 9 Chromosome Banding Chromosome Deletion Chromosomes Chromosomes, Human, Pair 9 deletion Dermatology DNA, Neoplasm - genetics DNA, Neoplasm - isolation & purification Genes Genetic loci Genetic Markers Genomics Homozygote Humans Hybrid cells Interferon-alpha - genetics Interferon-beta - genetics man Medical research Medical sciences Melanoma Melanoma - genetics Melanoma - surgery Membrane Glycoproteins Molecular Sequence Data Multigene Family Oligodeoxyribonucleotides Oxidoreductases Polymerase Chain Reaction - methods Proteins - genetics Skin cancer Tumor cell line Tumors Tumors of the skin and soft tissue. Premalignant lesions Human Skin disease Genetic marker Malignant tumor Flanking sequence C9-Chromosome Gene Malignant melanoma Gene rearrangement Deletion Interferon Skin Mutation Tumor suppressor gene
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