Irbesartan desmotropes: Solid-state characterization, thermodynamic study and dissolution properties

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2...

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Bibliographic Details
Published in:	Journal of pharmaceutical analysis Vol. 9; no. 5; pp. 339 - 346
Main Authors:	Araya-Sibaja, Andrea Mariela, Maduro de Campos, Carlos Eduardo, Fandaruff, Cinira, Vega-Baudrit, José Roberto, Guillén-Girón, Teodolito, Navarro-Hoyos, Mirtha, Cuffini, Silvia Lucía
Format:	Journal Article
Language:	English
Published:	China Elsevier B.V 01-10-2019 Xi'an Jiaotong University, Journal of Pharmaceutical Analysis Escuela de Química, Universidad de Costa Rica, San Pedro de Montes de Oca, 2060, San José, Costa Rica%Programa de Pós-Gradua??o em Física, Universidade Federal de Santa Catarina, Florianópolis, Brazil%Independent Researcher, 06472-005, Barueri, S?o Paulo, Brazil%Laboratorio Nacional de Nanotecnología LANOTEC-CeNAT-CONARE, 1174-1200, Pavas, San José, Costa Rica Laboratorio de Investigación y Tecnología de Polímeros POLIUNA, Escuela de Química, Universidad Nacional de Costa Rica, Heredia, 86-3000, Costa Rica%Escuela de Ciencia e Ingeniería de los Materiales, Tecnológico de Costa Rica, Cartago, 159-7050, Costa Rica%Escuela de Química, Universidad de Costa Rica, San Pedro de Montes de Oca, 2060, San José, Costa Rica%Instituto de Ciência e Técnica, Universidade Federal de S?o Paulo, S?o José dos Campos, S?o Paulo, Brazil Escuela de Ciencia e Ingeniería de los Materiales, Tecnológico de Costa Rica, Cartago, 159-7050, Costa Rica Laboratorio Nacional de Nanotecnología LANOTEC-CeNAT-CONARE, 1174-1200, Pavas, San José, Costa Rica Xi'an Jiaotong University Elsevier
Subjects:	Antihypertensives Bioavailability Desmotropic forms Differential scanning calorimetry Dissolution Feasibility studies Fourier transforms Intrinsic dissolution rate Irbesartan Microscopy Pharmaceutical industry Phase transitions Raman spectroscopy Raw materials Relative humidity Scanning electron microscopy Solid-state characterization Tautomerism X-ray diffraction Tautomerism Solid-state characterization Irbesartan Desmotropic forms Intrinsic dissolution rate
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