Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate

Schistosoma mansoni, administration of nitrobenzylthioinosine 5'-monophosphate with high doses of tubercidin (lethal doses if injected alone) by intraperitoneal injection into infected mice was highly toxic to parasite but not to host

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 80; no. 21; pp. 6667 - 6670
Main Authors:	El Kouni, M.H, Diop, D, Cha, S
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 01-11-1983 National Acad Sciences
Subjects:	Animals Biological Transport - drug effects Disease Models, Animal Drug Therapy, Combination Eggs Female Infections Inosine - analogs & derivatives Intraperitoneal injections Liver Mice Nucleosides Parasite hosts Parasites Perfusion Ribonucleosides - administration & dosage Schistosoma mansoni Schistosomiasis Schistosomiasis - drug therapy Thioinosine - administration & dosage Thioinosine - analogs & derivatives Thionucleotides - administration & dosage toxicity Tubercidin - administration & dosage Tubercidin - metabolism
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Description
Summary:	Schistosoma mansoni, administration of nitrobenzylthioinosine 5'-monophosphate with high doses of tubercidin (lethal doses if injected alone) by intraperitoneal injection into infected mice was highly toxic to parasite but not to host
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.80.21.6667