Overexpression of the LAR (Leukocyte Antigen-Related) Protein-Tyrosine Phosphatase in Muscle Causes Insulin Resistance

Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents, but it is not known whether these alterations contribute to the pathogenesis of insulin resistance....

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 98; no. 9; pp. 5187 - 5192
Main Authors:	Zabolotny, Janice M., Kim, Young-Bum, Peroni, Odile D., Kim, Jason K., Pani, Michael A., Boss, Olivier, Klaman, Lori D., Kamatkar, Shubhangi, Shulman, Gerald I., Kahn, Barbara B., Neel, Benjamin G.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 24-04-2001 National Acad Sciences The National Academy of Sciences
Subjects:	Animals Biological Sciences Blood Glucose - metabolism Body Composition Creatine Kinase - genetics Creatine Kinase, MM Form Diabetes Fatty Acids, Nonesterified - metabolism Humans Insulin Insulin - blood Insulin - pharmacology Insulin resistance Insulin Resistance - genetics Intracellular Signaling Peptides and Proteins Isoenzymes - genetics LAR protein Leukocytes Liver Mice Mice, Transgenic Muscles Muscles - drug effects Muscles - enzymology Muscles - metabolism Muscular system Obesity Organ Specificity Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphotyrosine - metabolism Promoter Regions, Genetic - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Proteins Receptors Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects White adipose tissue
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