Ischemic Lesion Growth in Patients with a Persistent Target Mismatch After Large Vessel Occlusion

• Published in: Clinical neuroradiology (Munich) Vol. 33; no. 1; pp. 41 - 48
• Main Authors: Tomari, Shinya, Lillicrap, Thomas, Garcia-Esperon, Carlos, Kashida, Yumi Tomari, Bivard, Andrew, Lin, Longting, Levi, Christopher R., Spratt, Neil J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2023; Springer; Springer Nature B.V
• Subjects: Brain Ischemia - diagnostic imaging; Brain research; Comparative analysis; CT imaging; Hospitals; Humans; Medical imaging; Medical imaging equipment; Medicine; Medicine & Public Health; Neurology; Neuroradiology; Neurosurgery; Original; Original Article; Patients; Retrospective Studies; Software; Stroke; Stroke - diagnostic imaging; Stroke - etiology; Stroke - pathology; Tomography, X-Ray Computed; Veins & arteries; Good collateral flow; Little core growth; CT perfusion collateral index; Persistent large penumbra; CT perfusion image
• DOI: 10.1007/s00062-022-01180-z
• EISSN: 1869-1447
• ISSN: 1869-1439

Background
Failure to reperfuse a cerebral occlusion resulting in a persistent penumbral pattern has not been fully described.
Methods
We retrospectively reviewed patients with anterior large vessel occlusion who did not receive reperfusion, and underwent repeated perfusion imaging, with baseline imaging < 6 h after onset and follow-up scans from 16–168 h. A persistent target mismatch (PTM) was defined as core volume of < 100 mL, mismatch ratio > 1.2, and mismatch volume > 10 mL on follow-up imaging. Patients were divided into PTM or non-PTM groups. Ischemic core and penumbral volumes were compared between baseline and follow-up imaging between the two groups, and collateral flow status assessed using CT perfusion collateral index.
Results
A total of 25 patients (14 PTM and 11 non-PTM) were enrolled in the study. Median core volumes increased slightly in the PTM group, from 22 to 36 ml. There was a much greater increase in the non-PTM group, from 57 to 190 ml. Penumbral volumes were stable in the PTM group from a median of 79 ml at baseline to 88 ml at follow-up, whereas penumbra was reduced in the non-PTM group, from 120 to 0 ml. Collateral flow status was also better in the PTM group and the median collateral index was 33% compared with 44% in the non-PTM group (
p
 = 0.043).
Conclusion
Multiple patients were identified with limited core growth and large penumbra (persistent target mismatch) > 16 h after stroke onset, likely due to more favorable collateral flow.