Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis

• Published in: American journal of human genetics Vol. 78; no. 6; pp. 1060 - 1065
• Main Authors: Ekelund, E., Sääf, A., Tengvall-Linder, M., Melen, E., Link, J., Barker, J., Reynolds, N.J., Meggitt, S.J., Kere, J., Wahlgren, C.-F., Pershagen, G., Wickman, M., Nordenskjöld, M., Kockum, I., Bradley, M.
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01-06-2006; University of Chicago Press; Cell Press; The American Society of Human Genetics
• Subjects: Adult; Allergic diseases; Biological and medical sciences; Chromosomes; Chromosomes, Human, Pair 17 - genetics; Deception; Dermatitis; Dermatitis, Atopic - genetics; Female; Gene Expression; General aspects. Genetic counseling; Genes; Genetic Linkage; Haplotypes; Humans; Immunopathology; Male; Medical genetics; Medical sciences; Medicin och hälsovetenskap; Monoclonal antibodies; Patients; Physical Chromosome Mapping; Polymorphism, Single Nucleotide; Risk factors; RNA, Messenger - metabolism; Skin - chemistry; Skin - metabolism; Skin - pathology; Skin allergic diseases. Stinging insect allergies; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins - analysis; Suppressor of Cytokine Signaling Proteins - genetics; Suppressor of Cytokine Signaling Proteins - metabolism; Up-Regulation; Human; Allergy; Immunopathology; Skin disease; Gene; Atopic dermatitis; Genetics; Gene expression; Genetic determinism; Atopy
• ISSN: 0002-9297; 1537-6605
• DOI: 10.1086/504272

In a systematic analysis of global gene-expression patterns, we found that
SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the
SOCS3 gene in two independent groups of patients (
P<.02 and
P<.03). These results strongly suggest that
SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.