Gene therapy for esophageal carcinoma: the use of an explant model to test adenoviral vectors ex vivo

Adenoviral gene therapy might be a promising therapeutic strategy for esophageal carcinoma. However, adenoviral transduction efficacy in vivo is still limited. This efficacy can be improved by the insertion of an Arg-Gly-Asp (RGD) peptide in the HI-loop of the viral fiber knob. Indeed in established...

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Bibliographic Details
Published in:	Cancer gene therapy Vol. 11; no. 4; pp. 289 - 296
Main Authors:	Marsman, Willem A, Buskens, Christianne J, Wesseling, John G, Offerhaus, G Johan A, Bergman, Jacques J G H M, Tytgat, Guido N J, van Lanschot, J Jan B, Bosma, Piter J
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-04-2004
Subjects:	Adenocarcinoma Adenoviridae - genetics Adenovirus Adenoviruses Barrett Esophagus - metabolism Barrett Esophagus - pathology Biopsy Carcinoma - metabolism Carcinoma - pathology Carcinoma - therapy Care and treatment Cell Line, Tumor Coxsackie and Adenovirus Receptor-Like Membrane Protein Epithelium Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagus Expression vectors Flow Cytometry Gene therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Health aspects Humans Immunochemistry Insertion Localization Metaplasia Methods Oligopeptides - genetics Oligopeptides - metabolism Receptors, Virus - analysis Squamous cell carcinoma Transduction Transduction, Genetic - methods Viability Netherlands
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