Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells

Aims/hypothesis Efficient stimulation of cycling activity in cultured beta cells would allow the design of new strategies for cell therapy in diabetes. Neural crest stem cells (NCSCs) play a role in beta cell development and maturation and increase the beta cell number in co-transplants. The mechani...

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Bibliographic Details
Published in:	Diabetologia Vol. 55; no. 7; pp. 2016 - 2025
Main Authors:	Grouwels, G., Vasylovska, S., Olerud, J., Leuckx, G., Ngamjariyawat, A., Yuchi, Y., Jansson, L., Van de Casteele, M., Kozlova, E. N., Heimberg, H.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01-07-2012 Springer Springer Nature B.V
Subjects:	Animals Beta cell Biological and medical sciences Blood Glucose - metabolism Cell culture Cell growth Cell Proliferation Cells, Cultured Coculture Techniques Deoxyuridine - pharmacology Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethics Etiopathogenesis. Screening. Investigations. Target tissue resistance Fibroblasts Glucose Growth factors Human Physiology Insulin Internal Medicine Islets of Langerhans - metabolism Islets of Langerhans Transplantation - methods Islets of Langerhans Transplantation - trends Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Neural crest Neural Crest - cytology Pancreas Proliferation Stem cells Transplants & implants United States > US Cell culture Diabetes Proliferation Neural crest Beta cell Endocrinopathy Cell proliferation Stem cell Diabetes mellitus Langerhans islet Rodentia In vitro Vertebrata Mammalia β Cell Endocrine pancreas
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