Does the method of primary treatment affect the pattern of first recurrence in high-grade serous ovarian cancer?

• Published in: Gynecologic oncology Vol. 155; no. 2; pp. 192 - 200
• Main Authors: Himoto, Yuki, Cybulska, Paulina, Shitano, Fuki, Sala, Evis, Zheng, Junting, Capanu, Marinela, Nougaret, Stephanie, Nikolovski, Ines, Vargas, Hebert A, Wang, Wei, Mueller, Jennifer J, Chi, Dennis S, Lakhman, Yulia
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2019
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Chemotherapy, Adjuvant; Complete gross resection; Computed tomography; Cystadenocarcinoma, Serous - drug therapy; Cystadenocarcinoma, Serous - pathology; Cystadenocarcinoma, Serous - surgery; Female; Hematology, Oncology, and Palliative Medicine; High-grade serous ovarian carcinoma; Humans; Middle Aged; Neoplasm Recurrence, Local - etiology; Neoplasm Recurrence, Local - pathology; Obstetrics and Gynecology; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Primary treatment; Recurrence; Retrospective Studies; Time Factors; Tomography, X-Ray Computed; Recurrence; Primary treatment; Computed tomography; Complete gross resection; High-grade serous ovarian carcinoma
• ISSN: 0090-8258; 1095-6859; 1095-6859
• DOI: 10.1016/j.ygyno.2019.08.011

AbstractPurposeTo determine if the primary treatment approach (primary debulking surgery (PDS) versus neoadjuvant chemotherapy and interval debulking surgery (NACT-IDS)) influences the pattern of first recurrence in patients with completely cytoreduced advanced high-grade serous ovarian carcinoma (HGSOC). Materials and methodsThis retrospective study included 178 patients with newly diagnosed stage IIIC–IV HGSOC, complete gross resection during PDS (n = 124) or IDS (n = 54) from January 2008–March 2013, and baseline and first recurrence contrast-enhanced computed tomography scans. Clinical characteristics and number of disease sites at baseline were analyzed for associations with time to recurrence. In 135 patients who experienced recurrence, the overlap in disease locations between baseline and recurrence and the number of new disease locations at recurrence were analyzed according to the primary treatment approach. ResultsAt univariate and multivariate analyses, NACT-IDS was associated with more overlapping locations between baseline and first recurrence (p ≤ 0.003) and fewer recurrences in new anatomic locations (p ≤ 0.043) compared with PDS. The same results were found in a subgroup that received intra-peritoneal adjuvant chemotherapy after either treatment approach. At univariate analysis, patient age, primary treatment approach, adjuvant chemotherapy route, and number of disease locations at baseline were associated with time to recurrence (p ≤ 0.009). At multivariate analysis, older patient age, NACT-IDS, and greater disease locations at baseline remained significant (p ≤ 0.018). ConclusionThe distribution of disease at the time of first recurrence varied with the choice of primary treatment. Compared to patients treated with PDS, patients who underwent NACT-IDS experienced recurrence more often in the same locations as the original disease.