Origin and initiation mechanisms of neuroblastoma

Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcript...

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Bibliographic Details
Published in:	Cell and tissue research Vol. 372; no. 2; pp. 211 - 221
Main Authors:	Tsubota, Shoma, Kadomatsu, Kenji
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2018 Springer Springer Nature B.V
Subjects:	Adrenal glands Adrenal medulla Adrenal Medulla - pathology Analysis Animal models Animals Biomedical and Life Sciences Biomedicine Carcinogenesis - pathology Children Chromaffin cells Chromaffin Cells - pathology Disease Models, Animal Epigenesis, Genetic Epigenetic inheritance Gene expression Genetic engineering Genetically modified animals Genomes Human Genetics Humans Malignancy Molecular Medicine Myc protein Neural crest Neural stem cells Neuroblastoma Neuroblastoma - genetics Neuroblastoma - pathology Pediatrics Polycomb group proteins Proteomics Review Reviews Sympathetic ganglia Sympathetic nervous system Schwann cell precursors MYCN Neuroblastoma Neural crest cells Sympathoadrenal progenitors
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