Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate
Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative...
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| Published in: | International journal of veterinary science and medicine Vol. 6; no. 1; pp. 80 - 89 |
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| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-06-2018
Taylor & Francis Faculty of Veterinary Medicine, Cairo University Taylor & Francis Group |
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| Abstract | Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600–850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure. |
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| AbstractList | Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600–850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure. Keywords: Air-pollution, Glutathione, Oxidative-stress, Protein carbonyl, Sulfhydryl, Vanadium Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600-850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure. Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600-850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure. |
| Author | Usende, Ifukibot L. Olopade, James O. Oyagbemi, Ademola A. Emikpe, Benjamin O. Adedapo, Adeolu A. |
| AuthorAffiliation | b Department of Veterinary Anatomy, University of Ibadan, Nigeria c Department of Veterinary Pathology, University of Ibadan, Nigeria d Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria e Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria a Department of Veterinary Anatomy, University of Abuja, Nigeria |
| AuthorAffiliation_xml | – name: d Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria – name: b Department of Veterinary Anatomy, University of Ibadan, Nigeria – name: a Department of Veterinary Anatomy, University of Abuja, Nigeria – name: c Department of Veterinary Pathology, University of Ibadan, Nigeria – name: e Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria |
| Author_xml | – sequence: 1 givenname: Ifukibot L. surname: Usende fullname: Usende, Ifukibot L. organization: Department of Veterinary Anatomy, University of Abuja, Nigeria – sequence: 2 givenname: James O. surname: Olopade fullname: Olopade, James O. organization: Department of Veterinary Anatomy, University of Ibadan, Nigeria – sequence: 3 givenname: Benjamin O. surname: Emikpe fullname: Emikpe, Benjamin O. organization: Department of Veterinary Pathology, University of Ibadan, Nigeria – sequence: 4 givenname: Ademola A. surname: Oyagbemi fullname: Oyagbemi, Ademola A. email: ademolaoyagbemi@yahoo.com organization: Department of Veterinary Physiology and Biochemistry, University of Ibadan, Nigeria – sequence: 5 givenname: Adeolu A. surname: Adedapo fullname: Adedapo, Adeolu A. organization: Department of Veterinary Pharmacology and Toxicology, University of Ibadan, Nigeria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30255083$$D View this record in MEDLINE/PubMed |
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| Copyright | 2018 Faculty of Veterinary Medicine, Cairo University Faculty of Veterinary Medicine, Cairo University 2018 2018 Faculty of Veterinary Medicine, Cairo University. Published by Elsevier B.V. 2018 Faculty of Veterinary Medicine, Cairo University |
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| Keywords | Oxidative-stress Protein carbonyl Vanadium Air-pollution Glutathione Sulfhydryl |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. open-access: http://creativecommons.org/licenses/by-nc-nd/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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| Title | Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate |
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