Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis

Osteoarthritis (OA) pain is most commonly characterized by movement-triggered joint pain. However, in advanced disease, OA pain becomes persistent, ongoing and resistant to treatment with nonsteroidal anti-inflammatory drugs (NSAIDs). The mechanisms underlying ongoing pain in advanced OA are poorly...

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Bibliographic Details
Published in:	The journal of pain Vol. 17; no. 3; p. 374
Main Authors:	Havelin, Joshua, Imbert, Ian, Cormier, Jennifer, Allen, Joshua, Porreca, Frank, King, Tamara
Format:	Journal Article
Language:	English
Published:	United States 01-03-2016
Subjects:	Analgesics - pharmacology Animals Arthralgia - drug therapy Arthralgia - physiopathology Central Nervous System Sensitization - drug effects Central Nervous System Sensitization - physiology Disease Models, Animal Dose-Response Relationship, Drug Duloxetine Hydrochloride - pharmacology Hindlimb Lidocaine - pharmacology Male Medulla Oblongata - drug effects Medulla Oblongata - physiopathology Neuralgia - drug therapy Neuralgia - physiopathology Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - physiopathology Proto-Oncogene Proteins c-fos - metabolism Rats, Sprague-Dawley Spinal Cord - drug effects Spinal Cord - physiopathology central sensitization descending facilitation duloxetine neuropathic pain Advanced osteoarthritis
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