Quantitative analysis of receptor-mediated uptake and pro-apoptotic activity of mistletoe lectin-1 by high content imaging

Ribosome inactivating proteins (RIPs) are highly potent cytotoxins that have potential as anticancer therapeutics. Mistletoe lectin 1 (ML1) is a heterodimeric cytotoxic protein isolated from European Mistletoe and belongs to RIP class II. The aim of this project was to systematically study ML1 cell...

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Bibliographic Details
Published in:	Scientific reports Vol. 8; no. 1; pp. 2768 - 10
Main Authors:	Beztsinna, N., de Matos, M. B. C., Walther, J., Heyder, C., Hildebrandt, E., Leneweit, G., Mastrobattista, E., Kok, R. J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09-02-2018 Nature Publishing Group Nature Portfolio
Subjects:	13/2 14/19 14/34 631/1647/245/2225 631/45/612/1235 82/1 82/16 82/83 Algorithms Apoptosis Automation Cancer Clathrin Cytotoxicity Cytotoxins Doxorubicin Endocytosis Endoplasmic reticulum Golgi apparatus Humanities and Social Sciences Image processing Lectins Localization Microscopy multidisciplinary Multidrug resistance Protein synthesis Proteins Quantitative analysis Science Science (multidisciplinary) Sugar Toxins
Online Access:	Get full text
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