Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review

The sulfonylurea receptor 1 (Sur1)-regulated NCCa-ATP channel is a nonselective cation channel that is regulated by intracellular calcium and adenosine triphosphate. The channel is not constitutively expressed, but is transcriptionally upregulated de novo in all cells of the neurovascular unit, in m...

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Bibliographic Details
Published in:	Journal of Cerebral Blood Flow & Metabolism Vol. 32; no. 9; pp. 1699 - 1717
Main Authors:	Simard, J Marc, Woo, S Kyoon, Schwartzbauer, Gary T, Gerzanich, Volodymyr
Format:	Book Review Journal Article
Language:	English
Published:	London, England SAGE Publications 01-09-2012 Nature Publishing Group Sage Publications Ltd
Subjects:	Animal models Animals ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette Transporters - physiology Biological and medical sciences Blood-Brain Barrier Brain Injuries - genetics Brain Injuries - metabolism Brain Ischemia - genetics Brain Ischemia - metabolism Calcium (intracellular) Cell Death Cell size Central nervous system Central Nervous System - injuries Central Nervous System - metabolism Cerebral blood flow Clinical trials Edema Gene Expression Regulation - genetics glibenclamide Humans Inflammation Intravenous administration Ischemia Medical sciences Metabolic diseases Microvasculature Necrosis Neurology Other metabolic disorders Pigments (porphyrias, hyperbilirubinemias...) Potassium Channels, Inwardly Rectifying - biosynthesis Potassium Channels, Inwardly Rectifying - drug effects Potassium Channels, Inwardly Rectifying - metabolism Potassium Channels, Inwardly Rectifying - physiology Receptors, Drug - biosynthesis Receptors, Drug - drug effects Receptors, Drug - metabolism Receptors, Drug - physiology Review Reviews Spinal Cord Injuries - genetics Spinal Cord Injuries - metabolism Spinal cord injury Stroke Sulfonylurea Receptors Suppression, Genetic Traumatic brain injury Up-Regulation Vascular diseases and vascular malformations of the nervous system spinal cord injury necrotic cell death cerebral ischemia subarachnoid hemorrhage Sur1 traumatic brain injury glibenclamide NCCa-ATP channel Central nervous system channel Cardiovascular disease Vascular disease Hypoglycemic agent Spinal cord trauma Glibenclamide Cerebrovascular disease Nervous system diseases Subarachnoid hemorrhage Cerebral disorder Sulfonamides Cell death NC Central nervous system disease Sulfonylureas Brain ischemia Head trauma Spinal cord disease ATP
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