Granulocytes, Macrophages, and Dendritic Cells Arise from a Common Major Histocompatibility Complex Class II-Negative Progenitor in Mouse Bone Marrow

The developmental origin of dendritic cells, a specialized system of major histocompatibility complex (MHC) class II-rich antigen-presenting cells for T-cell immunity and tolerance, is not well characterized. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to stimulate dendritic c...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 90; no. 7; pp. 3038 - 3042
Main Authors:	Inaba, Kayo, Inaba, Muneo, Deguchi, Masashi, Hagi, Katsuhiko, Yasumizu, Ryoji, Ikehara, Susumu, Muramatsu, Shigru, Steinman, Ralph M.
Format:	Journal Article
Language:	English
Published:	Washington, DC National Academy of Sciences of the United States of America 01-04-1993 National Acad Sciences National Academy of Sciences
Subjects:	Animals Antigens B lymphocytes Bacteria Biological and medical sciences Bone marrow Bone Marrow - immunology Bone Marrow Cells Cell Adhesion Cell Differentiation Cells, Cultured Cellular biology Crosses, Genetic Cultured cells Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Granulocytes Granulocytes - cytology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - immunology Histocompatibility Antigens Class II - analysis Immunity (Disease) Immunobiology Macrophages Macrophages - cytology Mice Mice, Inbred Strains Monoclonal antibodies Myeloid cells: ontogeny, maturation, markers, receptors Phagocytes Phenotype Polynuclears Rodents T lymphocytes Vacuoles - ultrastructure Dendritic cell Major histocompatibility system Cytokine Rodentia Class II histocompatibility antigen Granulocyte In vitro Precursor Vertebrata Phenotype Regulation(control) Mammalia Mouse Development Bone marrow Granulocyte macrophage colony stimulating factor Macrophage
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