Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat
► One day after stress treatment increased locomotor activity was observed. ► No effect on anxiety-behavior measured by the elevated plus maze activity. ► One day after stress treatment increased plasma corticosterone levels were observed. ► One day after stress treatment increased hypothalamic sero...
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| Published in: | Behavioural brain research Vol. 220; no. 1; pp. 106 - 111 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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| Abstract | ► One day after stress treatment increased locomotor activity was observed. ► No effect on anxiety-behavior measured by the elevated plus maze activity. ► One day after stress treatment increased plasma corticosterone levels were observed. ► One day after stress treatment increased hypothalamic serotonin activity was observed. ► A correlation between corticosterone and hypothalamic serotonin activity was found.
The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model effectively replicates depressive-like phenotypes; however, the ability of CUS to produce anxiety-like behaviors has not been adequately addressed. Using the CUS paradigm (2 stressors per day for 10 days) in adult Sprague-Dawley rats we identified behavioral, hormonal, and neurochemical changes one day after the cessation of treatment. Stress attenuated weight gain throughout the study and increased locomotor activity one day after treatment, but had no effect on anxiety-behavior as measured by the elevated plus maze. In addition, plasma corticosterone levels were positively correlated with hypothalamic serotonin (5-HT) activity one day after stress treatment as determined by the ratio of the metabolite 5-hydroxyindoleacetic acid (5-HIAA) to the parent compound (5-HIAA/5-HT ratio). These data suggest behavioral phenotypes associated with depression, but not comorbid anxiety, emerge in the immediate period after cessation of stress and that stress related physiology is related to 5-HT activity in the hypothalamus. |
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| AbstractList | ► One day after stress treatment increased locomotor activity was observed. ► No effect on anxiety-behavior measured by the elevated plus maze activity. ► One day after stress treatment increased plasma corticosterone levels were observed. ► One day after stress treatment increased hypothalamic serotonin activity was observed. ► A correlation between corticosterone and hypothalamic serotonin activity was found.
The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model effectively replicates depressive-like phenotypes; however, the ability of CUS to produce anxiety-like behaviors has not been adequately addressed. Using the CUS paradigm (2 stressors per day for 10 days) in adult Sprague-Dawley rats we identified behavioral, hormonal, and neurochemical changes one day after the cessation of treatment. Stress attenuated weight gain throughout the study and increased locomotor activity one day after treatment, but had no effect on anxiety-behavior as measured by the elevated plus maze. In addition, plasma corticosterone levels were positively correlated with hypothalamic serotonin (5-HT) activity one day after stress treatment as determined by the ratio of the metabolite 5-hydroxyindoleacetic acid (5-HIAA) to the parent compound (5-HIAA/5-HT ratio). These data suggest behavioral phenotypes associated with depression, but not comorbid anxiety, emerge in the immediate period after cessation of stress and that stress related physiology is related to 5-HT activity in the hypothalamus. The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model effectively replicates depressive-like phenotypes; however, the ability of CUS to produce anxiety-like behaviors has not been adequately addressed. Using the CUS paradigm (2 stressors per day for 10 days) in adult Sprague-Dawley rats we identified behavioral, hormonal, and neurochemical changes one day after the cessation of treatment. Stress attenuated weight gain throughout the study and increased locomotor activity one day after treatment, but had no effect on anxiety-behavior as measured by the elevated plus maze. In addition, plasma corticosterone levels were positively correlated with hypothalamic serotonin (5-HT) activity one day after stress treatment as determined by the ratio of the metabolite 5-hydroxyindoleacetic acid (5-HIAA) to the parent compound (5-HIAA/5-HT ratio). These data suggest behavioral phenotypes associated with depression, but not comorbid anxiety, emerge in the immediate period after cessation of stress and that stress related physiology is related to 5-HT activity in the hypothalamus. |
| Author | Perrine, Shane A. Alsawah, Fares McNeill, Peter C. Cox, Brittney M. Galloway, Matthew P. |
| AuthorAffiliation | 1 Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine 2 Department of Anesthesiology, Wayne State University School of Medicine |
| AuthorAffiliation_xml | – name: 1 Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine – name: 2 Department of Anesthesiology, Wayne State University School of Medicine |
| Author_xml | – sequence: 1 givenname: Brittney M. surname: Cox fullname: Cox, Brittney M. organization: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA – sequence: 2 givenname: Fares surname: Alsawah fullname: Alsawah, Fares organization: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA – sequence: 3 givenname: Peter C. surname: McNeill fullname: McNeill, Peter C. organization: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA – sequence: 4 givenname: Matthew P. surname: Galloway fullname: Galloway, Matthew P. organization: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA – sequence: 5 givenname: Shane A. surname: Perrine fullname: Perrine, Shane A. email: sperrine@med.wayne.edu organization: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA |
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| Cites_doi | 10.1016/j.neuroscience.2003.12.007 10.1016/S0306-4530(01)00092-0 10.1111/j.1532-5415.1987.tb02294.x 10.1159/000235904 10.1016/0091-3057(95)02173-6 10.1016/j.neuroscience.2009.01.067 10.1007/BF02244322 10.1007/s002130050456 10.1016/j.physbeh.2006.12.006 10.1097/00005053-199811000-00001 10.1016/0031-9384(95)02256-2 10.1046/j.1471-4159.2001.00665.x 10.1016/j.bbr.2008.06.008 10.1023/A:1019856821430 10.1016/0165-5728(94)00145-E 10.1210/edrv-5-1-25 10.1016/S0306-4530(96)00033-9 10.1016/S0166-4328(02)00222-X 10.1176/ajp.156.6.837 10.1523/JNEUROSCI.3223-04.2004 10.1016/S0014-2999(03)01285-8 10.1016/j.pnpbp.2009.07.020 10.1016/0091-3057(82)90053-3 10.1016/0006-8993(91)91379-F 10.1007/BF00187257 10.1016/j.beproc.2010.01.020 10.1017/S0033291705006069 10.1038/sj.npp.1301410 10.1007/s007020170077 10.1007/s00213-004-2103-4 10.1038/sj.bjp.0706686 10.1124/jpet.110.171322 10.1007/BF02246218 10.1073/pnas.96.25.14629 10.1016/0031-9384(94)90316-6 10.1016/S0149-7634(05)80194-0 10.1016/0893-133X(95)00152-4 |
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| Keywords | Chronic unpredictable stress Rat Serotonin Corticosterone Depression Anxiety Hypothalamus Locomotor activity Mood disorder Affect affectivity Steroid hormone Rodentia Central nervous system Glucocorticoid Stress Encephalon Locomotion Vertebrata Chronic Mammalia Animal Adrenal hormone Neurotransmitter Behavior |
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| References | Kendler, Karkowski, Prescott (bib0020) 1999; 156 Torres, Gamaro, Vasconcellos, Silveira, Dalmaz (bib0105) 2002; 27 Katz (bib0025) 1982; 16 Maslova, Bulygina, Markel (bib0125) 2002; 27 Li, Holmes, Ma, Van de Kar, Garcia, Murphy (bib0180) 2004; 24 Willner, Muscat, Papp (bib0035) 1992; 16 Grant, Hasin, Stinson, Dawson, June Ruan, Goldstein (bib0005) 2005; 35 Strausbaugh, Dallman, Levine (bib0100) 1999; 96 Willner, Towell, Sampson, Sophokleous, Muscat (bib0040) 1987; 93 Mangiavacchi, Masi, Scheggi, Leggio, De Montis, Gambarana (bib0200) 2001; 79 Dang, Chen, Liu, Wang, Wang, Jia (bib0090) 2009; 33 Ortiz, Fitzgerald, Lane, Terwilliger, Nestler (bib0065) 1996; 14 Deuschle, Schweiger, Standhardt, Weber, Heuser (bib0170) 1996; 21 Romer, Lewicka, Kopf, Lederbogen, Hamann, Gilles (bib0120) 2009; 90 Gorka, Moryl, Papp (bib0085) 1996; 54 Grippo, Sullivan, Damjanoska, Crane, Carrasco, Shi (bib0095) 2005; 179 Carrasco, Van de Kar (bib0175) 2003; 463 Johnson, Yamamoto (bib0190) 2009; 159 Institute of Laboratory Animal Resources (U.S.) (bib0150) 1996 Perrine, Hoshaw, Unterwald (bib0155) 2006; 147 Willner, Moreau, Nielsen, Papp, Sluzewska (bib0080) 1996; 60 Johnson, Yamamoto (bib0195) 2010; 335 Blanchard, Cholvanich, Blanchard, Clow, Hammer, Rowlett (bib0110) 1991; 568 Munck, Guyre, Holbrook (bib0115) 1984; 5 Paxinos, Watson (bib0160) 2007 Matuszewich, Yamamoto (bib0070) 2004; 124 Matuszewich, Karney, Carter, Janasik, O’Brien, Friedman (bib0145) 2007; 90 Kendler, Karkowski, Prescott (bib0015) 1998; 186 Stamford, Muscat, O’Connor, Patel, Trout, Wieczorek (bib0060) 1991; 105 Kompagne, Bardos, Szenasi, Gacsalyi, Harsing, Levay (bib0135) 2008; 193 Ossowska, Nowa, Kata, Klenk-Majewska, Danilczuk, Zebrowska-Lupina (bib0185) 2001; 108 Blazer, Bachar, Hughes (bib0010) 1987; 35 Willner (bib0030) 1997; 134 Bielajew, Konkle, Merali (bib0075) 2002; 136 Li, Zheng, Liang, Peng (bib0130) 2010; 83 American Psychiatric Association (bib0045) 2000 D’Aquila, Brain, Willner (bib0140) 1994; 56 Monleon, D’Aquila, Parra, Simon, Brain, Willner (bib0055) 1995; 117 Hermann, Beck, Sheridan (bib0165) 1995; 56 Bondi, Rodriguez, Gould, Frazer, Morilak (bib0050) 2008; 33 7860713 - J Neuroimmunol. 1995 Feb;56(2):179-86 1480349 - Neurosci Biobehav Rev. 1992 Winter;16(4):525-34 19409219 - Neuroscience. 2009 Apr 10;159(4):1233-43 8728562 - Pharmacol Biochem Behav. 1996 May;54(1):229-34 9824167 - J Nerv Ment Dis. 1998 Nov;186(11):661-9 9452163 - Psychopharmacology (Berl). 1997 Dec;134(4):319-29 15619113 - Psychopharmacology (Berl). 2005 Jun;179(4):769-80 11965354 - Psychoneuroendocrinology. 2002 Jul;27(5):549-61 19713693 - Neuroendocrinology. 2009;90(3):301-6 1726073 - Brain Res. 1991 Dec 24;568(1-2):61-6 7604147 - Psychopharmacology (Berl). 1995 Feb;117(4):453-7 7824585 - Physiol Behav. 1994 Nov;56(5):861-7 19632285 - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1417-24 11341483 - J Neural Transm (Vienna). 2001;108(3):311-9 3124165 - Psychopharmacology (Berl). 1987;93(3):358-64 8804652 - Physiol Behav. 1996 Jul;60(1):129-34 17406647 - Neuropsychopharmacology. 2008 Jan;33(2):320-31 16491101 - Br J Pharmacol. 2006 Apr;147(8):864-72 14980734 - Neuroscience. 2004;124(3):637-46 9247983 - Psychoneuroendocrinology. 1996 Nov;21(8):645-9 15574737 - J Neurosci. 2004 Dec 1;24(48):10868-77 3655175 - J Am Geriatr Soc. 1987 Oct;35(10):927-32 20123116 - Behav Processes. 2010 Mar;83(3):331-9 18590771 - Behav Brain Res. 2008 Nov 21;193(2):311-4 7202217 - Pharmacol Biochem Behav. 1982 Jun;16(6):965-8 12199158 - Neurochem Res. 2002 Jun;27(6):519-25 16202187 - Psychol Med. 2005 Dec;35(12):1747-59 12429420 - Behav Brain Res. 2002 Nov 15;136(2):583-92 10360120 - Am J Psychiatry. 1999 Jun;156(6):837-41 17275043 - Physiol Behav. 2007 Mar 16;90(4):674-81 11752052 - J Neurochem. 2001 Dec;79(6):1113-21 10588756 - Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14629-34 20634423 - J Pharmacol Exp Ther. 2010 Oct;335(1):180-9 8726755 - Neuropsychopharmacology. 1996 Jun;14(6):443-52 1796133 - Psychopharmacology (Berl). 1991;105(2):275-82 12600714 - Eur J Pharmacol. 2003 Feb 28;463(1-3):235-72 6368214 - Endocr Rev. 1984 Winter;5(1):25-44 Li (10.1016/j.bbr.2011.01.038_bib0130) 2010; 83 Ortiz (10.1016/j.bbr.2011.01.038_bib0065) 1996; 14 American Psychiatric Association (10.1016/j.bbr.2011.01.038_bib0045) 2000 Gorka (10.1016/j.bbr.2011.01.038_bib0085) 1996; 54 Blazer (10.1016/j.bbr.2011.01.038_bib0010) 1987; 35 Li (10.1016/j.bbr.2011.01.038_bib0180) 2004; 24 Mangiavacchi (10.1016/j.bbr.2011.01.038_bib0200) 2001; 79 Johnson (10.1016/j.bbr.2011.01.038_bib0195) 2010; 335 Perrine (10.1016/j.bbr.2011.01.038_bib0155) 2006; 147 Willner (10.1016/j.bbr.2011.01.038_bib0080) 1996; 60 Willner (10.1016/j.bbr.2011.01.038_bib0030) 1997; 134 Institute of Laboratory Animal Resources (U.S.) (10.1016/j.bbr.2011.01.038_bib0150) 1996 Johnson (10.1016/j.bbr.2011.01.038_bib0190) 2009; 159 Grant (10.1016/j.bbr.2011.01.038_bib0005) 2005; 35 Kendler (10.1016/j.bbr.2011.01.038_bib0020) 1999; 156 Strausbaugh (10.1016/j.bbr.2011.01.038_bib0100) 1999; 96 Ossowska (10.1016/j.bbr.2011.01.038_bib0185) 2001; 108 Stamford (10.1016/j.bbr.2011.01.038_bib0060) 1991; 105 Matuszewich (10.1016/j.bbr.2011.01.038_bib0070) 2004; 124 Blanchard (10.1016/j.bbr.2011.01.038_bib0110) 1991; 568 Matuszewich (10.1016/j.bbr.2011.01.038_bib0145) 2007; 90 Dang (10.1016/j.bbr.2011.01.038_bib0090) 2009; 33 Carrasco (10.1016/j.bbr.2011.01.038_bib0175) 2003; 463 Romer (10.1016/j.bbr.2011.01.038_bib0120) 2009; 90 Bondi (10.1016/j.bbr.2011.01.038_bib0050) 2008; 33 Paxinos (10.1016/j.bbr.2011.01.038_bib0160) 2007 D’Aquila (10.1016/j.bbr.2011.01.038_bib0140) 1994; 56 Bielajew (10.1016/j.bbr.2011.01.038_bib0075) 2002; 136 Deuschle (10.1016/j.bbr.2011.01.038_bib0170) 1996; 21 Katz (10.1016/j.bbr.2011.01.038_bib0025) 1982; 16 Torres (10.1016/j.bbr.2011.01.038_bib0105) 2002; 27 Maslova (10.1016/j.bbr.2011.01.038_bib0125) 2002; 27 Kendler (10.1016/j.bbr.2011.01.038_bib0015) 1998; 186 Hermann (10.1016/j.bbr.2011.01.038_bib0165) 1995; 56 Grippo (10.1016/j.bbr.2011.01.038_bib0095) 2005; 179 Kompagne (10.1016/j.bbr.2011.01.038_bib0135) 2008; 193 Willner (10.1016/j.bbr.2011.01.038_bib0035) 1992; 16 Willner (10.1016/j.bbr.2011.01.038_bib0040) 1987; 93 Monleon (10.1016/j.bbr.2011.01.038_bib0055) 1995; 117 Munck (10.1016/j.bbr.2011.01.038_bib0115) 1984; 5 |
| References_xml | – volume: 186 start-page: 661 year: 1998 end-page: 669 ident: bib0015 article-title: Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity publication-title: J Nerv Ment Dis contributor: fullname: Prescott – year: 1996 ident: bib0150 article-title: Guide for the care and use of laboratory animals contributor: fullname: Institute of Laboratory Animal Resources (U.S.) – volume: 90 start-page: 674 year: 2007 end-page: 681 ident: bib0145 article-title: The delayed effects of chronic unpredictable stress on anxiety measures publication-title: Physiol Behav contributor: fullname: Friedman – volume: 147 start-page: 864 year: 2006 end-page: 872 ident: bib0155 article-title: Delta opioid receptor ligands modulate anxiety-like behaviors in the rat publication-title: Br J Pharmacol contributor: fullname: Unterwald – volume: 568 start-page: 61 year: 1991 end-page: 66 ident: bib0110 article-title: Serotonin, but not dopamine, metabolites are increased in selected brain regions of subordinate male rats in a colony environment publication-title: Brain Res contributor: fullname: Rowlett – volume: 105 start-page: 275 year: 1991 end-page: 282 ident: bib0060 article-title: Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine publication-title: Psychopharmacology (Berl) contributor: fullname: Wieczorek – volume: 90 start-page: 301 year: 2009 end-page: 306 ident: bib0120 article-title: Cortisol metabolism in depressed patients and healthy controls publication-title: Neuroendocrinology contributor: fullname: Gilles – volume: 60 start-page: 129 year: 1996 end-page: 134 ident: bib0080 article-title: Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight publication-title: Physiol Behav contributor: fullname: Sluzewska – volume: 156 start-page: 837 year: 1999 end-page: 841 ident: bib0020 article-title: Causal relationship between stressful life events and the onset of major depression publication-title: Am J Psychiatry contributor: fullname: Prescott – volume: 193 start-page: 311 year: 2008 end-page: 314 ident: bib0135 article-title: Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats publication-title: Behav Brain Res contributor: fullname: Levay – volume: 79 start-page: 1113 year: 2001 end-page: 1121 ident: bib0200 article-title: Long-term behavioral and neurochemical effects of chronic stress exposure in rats publication-title: J Neurochem contributor: fullname: Gambarana – volume: 56 start-page: 179 year: 1995 end-page: 186 ident: bib0165 article-title: Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection publication-title: J Neuroimmunol contributor: fullname: Sheridan – volume: 335 start-page: 180 year: 2010 end-page: 189 ident: bib0195 article-title: Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature publication-title: J Pharmacol Exp Ther contributor: fullname: Yamamoto – volume: 33 start-page: 1417 year: 2009 end-page: 1424 ident: bib0090 article-title: Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry contributor: fullname: Jia – volume: 96 start-page: 14629 year: 1999 end-page: 14634 ident: bib0100 article-title: Repeated, but not acute, stress suppresses inflammatory plasma extravasation publication-title: Proc Natl Acad Sci USA contributor: fullname: Levine – volume: 108 start-page: 311 year: 2001 end-page: 319 ident: bib0185 article-title: Brain monoamine receptors in a chronic unpredictable stress model in rats publication-title: J Neural Transm contributor: fullname: Zebrowska-Lupina – volume: 134 start-page: 319 year: 1997 end-page: 329 ident: bib0030 article-title: Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation publication-title: Psychopharmacology (Berl) contributor: fullname: Willner – volume: 24 start-page: 10868 year: 2004 end-page: 10877 ident: bib0180 article-title: Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences publication-title: J Neurosci contributor: fullname: Murphy – volume: 16 start-page: 525 year: 1992 end-page: 534 ident: bib0035 article-title: Chronic mild stress-induced anhedonia: a realistic animal model of depression publication-title: Neurosci Biobehav Rev contributor: fullname: Papp – volume: 179 start-page: 769 year: 2005 end-page: 780 ident: bib0095 article-title: Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats publication-title: Psychopharmacology (Berl) contributor: fullname: Shi – volume: 27 start-page: 549 year: 2002 end-page: 561 ident: bib0125 article-title: Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior publication-title: Psychoneuroendocrinology contributor: fullname: Markel – volume: 5 start-page: 25 year: 1984 end-page: 44 ident: bib0115 article-title: Physiological functions of glucocorticoids in stress and their relation to pharmacological actions publication-title: Endocr Rev contributor: fullname: Holbrook – volume: 14 start-page: 443 year: 1996 end-page: 452 ident: bib0065 article-title: Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress publication-title: Neuropsychopharmacology contributor: fullname: Nestler – year: 2007 ident: bib0160 article-title: The rat brain in stereotaxic coordinates contributor: fullname: Watson – volume: 136 start-page: 583 year: 2002 end-page: 592 ident: bib0075 article-title: The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analyses publication-title: Behav Brain Res contributor: fullname: Merali – year: 2000 ident: bib0045 article-title: Task force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV-TR contributor: fullname: American Psychiatric Association – volume: 56 start-page: 861 year: 1994 end-page: 867 ident: bib0140 article-title: Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression publication-title: Physiol Behav contributor: fullname: Willner – volume: 463 start-page: 235 year: 2003 end-page: 272 ident: bib0175 article-title: Neuroendocrine pharmacology of stress publication-title: Eur J Pharmacol contributor: fullname: Van de Kar – volume: 124 start-page: 637 year: 2004 end-page: 646 ident: bib0070 article-title: Chronic stress augments the long-term and acute effects of methamphetamine publication-title: Neuroscience contributor: fullname: Yamamoto – volume: 35 start-page: 1747 year: 2005 end-page: 1759 ident: bib0005 article-title: Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions publication-title: Psychol Med contributor: fullname: Goldstein – volume: 33 start-page: 320 year: 2008 end-page: 331 ident: bib0050 article-title: Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment publication-title: Neuropsychopharmacology contributor: fullname: Morilak – volume: 35 start-page: 927 year: 1987 end-page: 932 ident: bib0010 article-title: Major depression with melancholia: a comparison of middle-aged and elderly adults publication-title: J Am Geriatr Soc contributor: fullname: Hughes – volume: 21 start-page: 645 year: 1996 end-page: 649 ident: bib0170 article-title: Corticosteroid-binding globulin is not decreased in depressed patients publication-title: Psychoneuroendocrinology contributor: fullname: Heuser – volume: 54 start-page: 229 year: 1996 end-page: 234 ident: bib0085 article-title: Effect of chronic mild stress on circadian rhythms in the locomotor activity in rats publication-title: Pharmacol Biochem Behav contributor: fullname: Papp – volume: 27 start-page: 519 year: 2002 end-page: 525 ident: bib0105 article-title: Effects of chronic restraint stress on feeding behavior and on monoamine levels in different brain structures in rats publication-title: Neurochem Res contributor: fullname: Dalmaz – volume: 159 start-page: 1233 year: 2009 end-page: 1243 ident: bib0190 article-title: Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone publication-title: Neuroscience contributor: fullname: Yamamoto – volume: 16 start-page: 965 year: 1982 end-page: 968 ident: bib0025 article-title: Animal model of depression: pharmacological sensitivity of a hedonic deficit publication-title: Pharmacol Biochem Behav contributor: fullname: Katz – volume: 83 start-page: 331 year: 2010 end-page: 339 ident: bib0130 article-title: Coexistence of anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression publication-title: Behav Processes contributor: fullname: Peng – volume: 93 start-page: 358 year: 1987 end-page: 364 ident: bib0040 article-title: Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant publication-title: Psychopharmacology (Berl) contributor: fullname: Muscat – volume: 117 start-page: 453 year: 1995 end-page: 457 ident: bib0055 article-title: Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine publication-title: Psychopharmacology (Berl) contributor: fullname: Willner – volume: 124 start-page: 637 year: 2004 ident: 10.1016/j.bbr.2011.01.038_bib0070 article-title: Chronic stress augments the long-term and acute effects of methamphetamine publication-title: Neuroscience doi: 10.1016/j.neuroscience.2003.12.007 contributor: fullname: Matuszewich – volume: 27 start-page: 549 year: 2002 ident: 10.1016/j.bbr.2011.01.038_bib0125 article-title: Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(01)00092-0 contributor: fullname: Maslova – volume: 35 start-page: 927 year: 1987 ident: 10.1016/j.bbr.2011.01.038_bib0010 article-title: Major depression with melancholia: a comparison of middle-aged and elderly adults publication-title: J Am Geriatr Soc doi: 10.1111/j.1532-5415.1987.tb02294.x contributor: fullname: Blazer – volume: 90 start-page: 301 year: 2009 ident: 10.1016/j.bbr.2011.01.038_bib0120 article-title: Cortisol metabolism in depressed patients and healthy controls publication-title: Neuroendocrinology doi: 10.1159/000235904 contributor: fullname: Romer – volume: 54 start-page: 229 year: 1996 ident: 10.1016/j.bbr.2011.01.038_bib0085 article-title: Effect of chronic mild stress on circadian rhythms in the locomotor activity in rats publication-title: Pharmacol Biochem Behav doi: 10.1016/0091-3057(95)02173-6 contributor: fullname: Gorka – volume: 159 start-page: 1233 year: 2009 ident: 10.1016/j.bbr.2011.01.038_bib0190 article-title: Chronic unpredictable stress augments +3,4-methylenedioxymethamphetamine-induced monoamine depletions: the role of corticosterone publication-title: Neuroscience doi: 10.1016/j.neuroscience.2009.01.067 contributor: fullname: Johnson – year: 2000 ident: 10.1016/j.bbr.2011.01.038_bib0045 contributor: fullname: American Psychiatric Association – volume: 105 start-page: 275 year: 1991 ident: 10.1016/j.bbr.2011.01.038_bib0060 article-title: Voltammetric evidence that subsensitivity to reward following chronic mild stress is associated with increased release of mesolimbic dopamine publication-title: Psychopharmacology (Berl) doi: 10.1007/BF02244322 contributor: fullname: Stamford – volume: 134 start-page: 319 year: 1997 ident: 10.1016/j.bbr.2011.01.038_bib0030 article-title: Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation publication-title: Psychopharmacology (Berl) doi: 10.1007/s002130050456 contributor: fullname: Willner – volume: 90 start-page: 674 year: 2007 ident: 10.1016/j.bbr.2011.01.038_bib0145 article-title: The delayed effects of chronic unpredictable stress on anxiety measures publication-title: Physiol Behav doi: 10.1016/j.physbeh.2006.12.006 contributor: fullname: Matuszewich – volume: 186 start-page: 661 year: 1998 ident: 10.1016/j.bbr.2011.01.038_bib0015 article-title: Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity publication-title: J Nerv Ment Dis doi: 10.1097/00005053-199811000-00001 contributor: fullname: Kendler – volume: 60 start-page: 129 year: 1996 ident: 10.1016/j.bbr.2011.01.038_bib0080 article-title: Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight publication-title: Physiol Behav doi: 10.1016/0031-9384(95)02256-2 contributor: fullname: Willner – volume: 79 start-page: 1113 year: 2001 ident: 10.1016/j.bbr.2011.01.038_bib0200 article-title: Long-term behavioral and neurochemical effects of chronic stress exposure in rats publication-title: J Neurochem doi: 10.1046/j.1471-4159.2001.00665.x contributor: fullname: Mangiavacchi – volume: 193 start-page: 311 year: 2008 ident: 10.1016/j.bbr.2011.01.038_bib0135 article-title: Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats publication-title: Behav Brain Res doi: 10.1016/j.bbr.2008.06.008 contributor: fullname: Kompagne – volume: 27 start-page: 519 year: 2002 ident: 10.1016/j.bbr.2011.01.038_bib0105 article-title: Effects of chronic restraint stress on feeding behavior and on monoamine levels in different brain structures in rats publication-title: Neurochem Res doi: 10.1023/A:1019856821430 contributor: fullname: Torres – volume: 56 start-page: 179 year: 1995 ident: 10.1016/j.bbr.2011.01.038_bib0165 article-title: Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection publication-title: J Neuroimmunol doi: 10.1016/0165-5728(94)00145-E contributor: fullname: Hermann – volume: 5 start-page: 25 year: 1984 ident: 10.1016/j.bbr.2011.01.038_bib0115 article-title: Physiological functions of glucocorticoids in stress and their relation to pharmacological actions publication-title: Endocr Rev doi: 10.1210/edrv-5-1-25 contributor: fullname: Munck – year: 1996 ident: 10.1016/j.bbr.2011.01.038_bib0150 contributor: fullname: Institute of Laboratory Animal Resources (U.S.) – volume: 21 start-page: 645 year: 1996 ident: 10.1016/j.bbr.2011.01.038_bib0170 article-title: Corticosteroid-binding globulin is not decreased in depressed patients publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(96)00033-9 contributor: fullname: Deuschle – volume: 136 start-page: 583 year: 2002 ident: 10.1016/j.bbr.2011.01.038_bib0075 article-title: The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analyses publication-title: Behav Brain Res doi: 10.1016/S0166-4328(02)00222-X contributor: fullname: Bielajew – volume: 156 start-page: 837 year: 1999 ident: 10.1016/j.bbr.2011.01.038_bib0020 article-title: Causal relationship between stressful life events and the onset of major depression publication-title: Am J Psychiatry doi: 10.1176/ajp.156.6.837 contributor: fullname: Kendler – volume: 24 start-page: 10868 year: 2004 ident: 10.1016/j.bbr.2011.01.038_bib0180 article-title: Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3223-04.2004 contributor: fullname: Li – volume: 463 start-page: 235 year: 2003 ident: 10.1016/j.bbr.2011.01.038_bib0175 article-title: Neuroendocrine pharmacology of stress publication-title: Eur J Pharmacol doi: 10.1016/S0014-2999(03)01285-8 contributor: fullname: Carrasco – volume: 33 start-page: 1417 year: 2009 ident: 10.1016/j.bbr.2011.01.038_bib0090 article-title: Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2009.07.020 contributor: fullname: Dang – volume: 16 start-page: 965 year: 1982 ident: 10.1016/j.bbr.2011.01.038_bib0025 article-title: Animal model of depression: pharmacological sensitivity of a hedonic deficit publication-title: Pharmacol Biochem Behav doi: 10.1016/0091-3057(82)90053-3 contributor: fullname: Katz – volume: 568 start-page: 61 year: 1991 ident: 10.1016/j.bbr.2011.01.038_bib0110 article-title: Serotonin, but not dopamine, metabolites are increased in selected brain regions of subordinate male rats in a colony environment publication-title: Brain Res doi: 10.1016/0006-8993(91)91379-F contributor: fullname: Blanchard – volume: 93 start-page: 358 year: 1987 ident: 10.1016/j.bbr.2011.01.038_bib0040 article-title: Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant publication-title: Psychopharmacology (Berl) doi: 10.1007/BF00187257 contributor: fullname: Willner – volume: 83 start-page: 331 year: 2010 ident: 10.1016/j.bbr.2011.01.038_bib0130 article-title: Coexistence of anhedonia and anxiety-independent increased novelty-seeking behavior in the chronic mild stress model of depression publication-title: Behav Processes doi: 10.1016/j.beproc.2010.01.020 contributor: fullname: Li – year: 2007 ident: 10.1016/j.bbr.2011.01.038_bib0160 contributor: fullname: Paxinos – volume: 35 start-page: 1747 year: 2005 ident: 10.1016/j.bbr.2011.01.038_bib0005 article-title: Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions publication-title: Psychol Med doi: 10.1017/S0033291705006069 contributor: fullname: Grant – volume: 33 start-page: 320 year: 2008 ident: 10.1016/j.bbr.2011.01.038_bib0050 article-title: Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301410 contributor: fullname: Bondi – volume: 108 start-page: 311 year: 2001 ident: 10.1016/j.bbr.2011.01.038_bib0185 article-title: Brain monoamine receptors in a chronic unpredictable stress model in rats publication-title: J Neural Transm doi: 10.1007/s007020170077 contributor: fullname: Ossowska – volume: 179 start-page: 769 year: 2005 ident: 10.1016/j.bbr.2011.01.038_bib0095 article-title: Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats publication-title: Psychopharmacology (Berl) doi: 10.1007/s00213-004-2103-4 contributor: fullname: Grippo – volume: 147 start-page: 864 year: 2006 ident: 10.1016/j.bbr.2011.01.038_bib0155 article-title: Delta opioid receptor ligands modulate anxiety-like behaviors in the rat publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0706686 contributor: fullname: Perrine – volume: 335 start-page: 180 year: 2010 ident: 10.1016/j.bbr.2011.01.038_bib0195 article-title: Chronic stress enhances the corticosterone response and neurotoxicity to +3,4-methylenedioxymethamphetamine (MDMA): the role of ambient temperature publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.110.171322 contributor: fullname: Johnson – volume: 117 start-page: 453 year: 1995 ident: 10.1016/j.bbr.2011.01.038_bib0055 article-title: Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine publication-title: Psychopharmacology (Berl) doi: 10.1007/BF02246218 contributor: fullname: Monleon – volume: 96 start-page: 14629 year: 1999 ident: 10.1016/j.bbr.2011.01.038_bib0100 article-title: Repeated, but not acute, stress suppresses inflammatory plasma extravasation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.96.25.14629 contributor: fullname: Strausbaugh – volume: 56 start-page: 861 year: 1994 ident: 10.1016/j.bbr.2011.01.038_bib0140 article-title: Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression publication-title: Physiol Behav doi: 10.1016/0031-9384(94)90316-6 contributor: fullname: D’Aquila – volume: 16 start-page: 525 year: 1992 ident: 10.1016/j.bbr.2011.01.038_bib0035 article-title: Chronic mild stress-induced anhedonia: a realistic animal model of depression publication-title: Neurosci Biobehav Rev doi: 10.1016/S0149-7634(05)80194-0 contributor: fullname: Willner – volume: 14 start-page: 443 year: 1996 ident: 10.1016/j.bbr.2011.01.038_bib0065 article-title: Biochemical adaptations in the mesolimbic dopamine system in response to repeated stress publication-title: Neuropsychopharmacology doi: 10.1016/0893-133X(95)00152-4 contributor: fullname: Ortiz |
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| Snippet | ► One day after stress treatment increased locomotor activity was observed. ► No effect on anxiety-behavior measured by the elevated plus maze activity. ► One... The high comorbidity of anxiety and depression suggests a potential degree of commonality in their etiologies. The chronic unpredictable stress (CUS) model... |
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| SubjectTerms | Adult and adolescent clinical studies Animals Anxiety Anxiety - physiopathology Behavior, Animal - drug effects Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Brain - metabolism Chromatography, High Pressure Liquid - methods Chronic Disease Chronic unpredictable stress Corticosterone Corticosterone - blood Depression Disease Models, Animal Enzyme-Linked Immunosorbent Assay - methods Fundamental and applied biological sciences. Psychology Hydroxyindoleacetic Acid - metabolism Hypothalamus Hypothalamus - metabolism Hypothalamus - pathology Locomotor activity Male Maze Learning - physiology Medical sciences Mood disorders Motor Activity - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rat Rats Rats, Sprague-Dawley Serotonin Serotonin - metabolism Statistics as Topic Stress, Psychological - metabolism Stress, Psychological - pathology Stress, Psychological - physiopathology Weight Gain - physiology |
| Title | Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat |
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