Oxidation of Myofibrillar Proteins in Human Heart Failure

Objectives We investigated the incidence and contribution of the oxidation/nitrosylation of tropomyosin and actin to the contractile impairment and cardiomyocyte injury occurring in human end-stage heart failure (HF) as compared with nonfailing donor hearts. Background Although there is growing evid...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 57; no. 3; pp. 300 - 309
Main Authors:	Canton, Marcella, PhD, Menazza, Sara, MSc, Sheeran, Freya L., PhD, Polverino de Laureto, Patrizia, PhD, Di Lisa, Fabio, MD, Pepe, Salvatore, PhD
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 18-01-2011 Elsevier Elsevier Limited
Subjects:	Actins - metabolism Adult Aged Biological and medical sciences Biopsy Blood & organ donations Brain death Cardiology Cardiology. Vascular system Cardiomyopathy Cardiovascular Cloning Contractile Proteins - metabolism Female Gene expression Heart Heart failure Heart Failure - metabolism Heart Failure - pathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Internal Medicine Male Medical sciences Membranes Middle Aged Mortality myofibrillar proteins Oxidation-Reduction Oxidative stress Oxidative Stress - physiology Proteins reactive oxygen species Reactive Oxygen Species - metabolism Rodents Software Studies Tropomyosin - metabolism United States > US California heart failure cTnI DCB MP LVEF LV left ventricular ejection fraction myofibrillar protein cardiac troponin I nonfailing disulphide cross-bridge tropomyosin reactive oxygen species ROS NF Tm myofibrillar proteins left ventricular HF Human Heart failure Heart disease Cardiovascular disease Oxidation Circulatory system Cardiology Protein
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