Graves' Hyperthyroidism Following Transient Thyrotoxicosis during Interferon Therapy for Chronic Hepatitis Type C
We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.A 52-year-old woman suffered from chronic active hepatitis type C and was treated with a total of 456×106 units of IFN-α for 23 weeks. During the 12th week of treatment she showed transient thyrotoxicosis....
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| Published in: | Internal Medicine Vol. 34; no. 1; pp. 58 - 60 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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The Japanese Society of Internal Medicine
1995
Japanese Society of Internal Medicine |
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| Abstract | We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.A 52-year-old woman suffered from chronic active hepatitis type C and was treated with a total of 456×106 units of IFN-α for 23 weeks. During the 12th week of treatment she showed transient thyrotoxicosis. One week after the termination of IFN therapy, TSH-receptor antibodies became positive and subsequently she showed Graves' hyperthyroidism. This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy. The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism. (Internal Medicine 34: 58-60, 1995) |
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| AbstractList | We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy. A 52-year-old woman suffered from chronic active hepatitis type C and was treated with a total of 456 x 10(6) units of IFN-alpha for 23 weeks. During the 12th week of treatment she showed transient thyrotoxicosis. One week after the termination of IFN therapy, TSH-receptor antibodies became positive and subsequently she showed Graves' hyperthyroidism. This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy. The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism. We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.A 52-year-old woman suffered from chronic active hepatitis type C and was treated with a total of 456×106 units of IFN-α for 23 weeks. During the 12th week of treatment she showed transient thyrotoxicosis. One week after the termination of IFN therapy, TSH-receptor antibodies became positive and subsequently she showed Graves' hyperthyroidism. This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy. The course of this case may be useful in the understanding of the pathogenesis of autoimmune hyperthyroidism. (Internal Medicine 34: 58-60, 1995) |
| Author | MIZUO, Hitoshi MATSUYA, Kumiko MASHIO, Yasuo MATSUDA, Akira IRIUDA, Yoshiyori KOIZUMI, Shigeki BENIKO, Mutsuo MIZUMOTO, Hiroaki IKOTA, Akemi |
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| Keywords | Endocrinopathy Human Toxicity Hyperthyroidism Thyroid diseases Autoimmune disease Transitory Case study Immunomodulator Chemotherapy Graves disease Antiviral Female Interferon Long lasting |
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| References | 4) Lisker-Melman M, Di Bisceglie AM, Usala SJ, Weintraub B, Murray LM, Hoofnagle JH. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa. Gastroenterol 102: 2155, 1992. 7) Abe T, Suga M, Ono A, et al. A case of hyperthyroidism appeared during interferon treatment for chronic hepatitis C. Nippon Shokakibyo Gakkai Zasshi 90: 818, 1993 (in Japanese). 3) Burman P, Karlsson FA, Oberg K, Aim G. Autoimmune thyroid disease in interferon-treated patients. Lancet 100, 1985. 5) Papo T, Oksenhendler E, Izembart M, Leger A, Clauvel J-P. Antithyroid hormone antibodies induced by interferon-α. J Clin Endocrinol Metab 75: 1484, 1992. 10) Golub SH. Immunological and therapeutic effects of interferon treatment of cancer patients. Clin Immunol Allergy 4: 377, 1984. 14) Daniels HM, Meager A, Eddleston ALWF, et al. Spontaneous production of tumour necrosis factor a and interleukin-16 during interferon-α treatment of chronic HBV infection. Lancet 335: 875, 1990. 6) Taniguchi Y, Murakami T, Nakanishi K, et al. Two cases of hypothyroidism associated with alpha-interferon therapy. Intern Medicine 31: 373, 1992. 1) Davis TF. New thinking on the immunology of Graves' disease. Thyroid Today 15: 1, 1992. 13) Mayet W-J, Hess G, Gerken G, et al. Treatment of chronic type B hepatitis with recombinant α-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology 10: 24, 1989. 8) Mashio Y, Beniko B, Ikota A, Mizumoto H, Kunita H. Treatment of hyperthyroidism with a small single daily dose of methimazole. Acta Endocrinologica (Copenh) 119: 139, 1988. 11) Hanafusa T, Pujol-Borrell R, Chiovato L, et al. Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 2: 1111, 1983. 12) Jansson R, Karlsson A, Forsum U. Intrathyroidal HLA-DR expression and T lymphocyte phenotypes in Graves' thyrotoxicosis, Hashimoto's thyroiditis and nodular colloid goitre. Clin Exp Immunol 58: 264,1984. 17) Wartofsky L. Graves' disease with thyrotoxicosis following subacute thyroiditis. Am J Med 83: 761, 1987. 16) Werner SC. Graves' disease following acute (subacute) thyroiditis. Arch Intern Med 139: 1313, 1979. 15) Sheets RF. The sequential occurrence of acute thyroiditis and thyrotoxicosis. JAMA 157: 139, 1955. 2) Fentiman IS, Thomas BS, Balkwill FR, Rubens RD, Hayward JL. Primary hypothyroidism associated with interferon therapy of breast cancer. Lancet 1166, 1985. 9) Kasagi K, Konishi J, Arai K, et al. A sensitive and practical assay for thyroid-stimulating antibodies using crude immunoglobulin fractions precipitated with polyethylene glycol. J Clin Endocrinol Metab 62: 855, 1986. |
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| Snippet | We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.A 52-year-old woman suffered from chronic active hepatitis type C and... We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy. A 52-year-old woman suffered from chronic active hepatitis type C... |
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| SubjectTerms | Autoantibodies - blood autoimmunity Biological and medical sciences Drug toxicity and drugs side effects treatment Female Graves Disease - chemically induced Graves Disease - immunology Hepatitis C - drug therapy Hepatitis C - immunology Hepatitis, Chronic - drug therapy Hepatitis, Chronic - immunology Humans Interferon-alpha - adverse effects Interferon-alpha - immunology Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Radioimmunoassay Receptors, Thyrotropin - immunology Thyrotoxicosis - complications TSH-receptor antibody |
| Title | Graves' Hyperthyroidism Following Transient Thyrotoxicosis during Interferon Therapy for Chronic Hepatitis Type C |
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