A human monoclonal antibody derived from a vaccinated volunteer recognizes heterosubtypically a novel epitope on the hemagglutinin globular head of H1 and H9 influenza A viruses

•A human monoclonal antibody against influenza virus was produced from a volunteer.•The antibody was generated from the PBMCs of the volunteer using the fusion method.•The antibody neutralized heterosubtypically group 1 influenza A viruses (H1 and H9).•The antibody targeted a novel epitope in globul...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 452; no. 3; pp. 865 - 870
Main Authors:	Boonsathorn, Naphatsawan, Panthong, Sumolrat, Koksunan, Sarawut, Chittaganpitch, Malinee, Phuygun, Siripaporn, Waicharoen, Sunthareeya, Prachasupap, Apichai, Sasaki, Tadahiro, Kubota-Koketsu, Ritsuko, Yasugi, Mayo, Ono, Ken-ichiro, Arai, Yasuha, Kurosu, Takeshi, Sawanpanyalert, Pathom, Ikuta, Kazuyoshi, Watanabe, Yohei
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 26-09-2014
Subjects:	60 APPLIED LIFE SCIENCES Amino Acid Sequence AMINO ACIDS Animals Antibodies, Monoclonal - biosynthesis Antibodies, Neutralizing - biosynthesis Antibodies, Viral - biosynthesis Antigens, Viral - chemistry Antigens, Viral - immunology Conserved epitope in HA head region Cross Protection Epitope Mapping Epitopes - chemistry Epitopes - immunology Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Heterosubtypic neutralizing antibody Human monoclonal antibody HUMAN POPULATIONS Humans Hybridomas - immunology INFLUENZA Influenza A virus Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H9N2 Subtype - immunology Influenza Vaccines - administration & dosage INFLUENZA VIRUSES Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology INHIBITION LYMPHOCYTES Male Mice Models, Molecular Molecular Sequence Data MONOCLONAL ANTIBODIES MUTANTS Protein Conformation RECEPTORS RESIDUES Vaccination VACCINES Young Adult Influenza A virus Heterosubtypic neutralizing antibody Conserved epitope in HA head region Human monoclonal antibody
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