Molecular Genetics of Atrial Fibrillation

• Published in: Journal of the American College of Cardiology Vol. 52; no. 4; pp. 241 - 250
• Main Authors: Tsai, Chia-Ti, MD, PhD, Lai, Ling-Ping, MD, PhD, Hwang, Juey-Jen, MD, PhD, Lin, Jiunn-Lee, MD, PhD, Chiang, Fu-Tien, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 22-07-2008; Elsevier Science; Elsevier Limited
• Subjects: atrial fibrillation; Atrial Fibrillation - genetics; Atrial Fibrillation - physiopathology; Biological and medical sciences; Cardiac arrhythmia; Cardiac dysrhythmias; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Circuits; Clinical medicine; Deoxyribonucleic acid; DNA; familial; Genes; Genetic Diseases, Inborn - genetics; Genetics; Heart; Humans; Hypertension; Inflammation - genetics; Internal Medicine; Medical sciences; multifactorial; Mutation; Potassium; Potassium Channels - genetics; Risk Factors; Rodents; Sodium Channels - genetics; Studies; inward rectifier potassium current; sarcolipin; OR; long QT syndrome; AF; RAS; single nucleotide polymorphism; CI; LQTS; multifactorial; odds ratio; IK1; rapidly activating delayed rectifier potassium current; IKs; familial; IKr; slowly activating delayed rectifier potassium current; atrial fibrillation; genetics; SLN; SNP; confidence interval; renin-angiotensin system; Arrhythmia; Heart disease; Atrial fibrillation; Cardiovascular disease; Genetics; Circulatory system; Cardiology; Excitability disorder
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2008.02.072

Molecular Genetics of Atrial Fibrillation Chia-Ti Tsai, Ling-Ping Lai, Juey-Jen Hwang, Jiunn-Lee Lin, Fu-Tien Chiang There is a genetic predisposition for development of atrial fibrillation (AF). Several loci have been found for monogenetic or familial AF. All of the known mutations are associated with a gain of function of repolarization potassium currents. In addition to familial AF, genetic polymorphisms related to mechanisms of AF have been found to be associated with common AF, including genes encoding for ionic channels, sarcolipin gene, renin-angiotensin system genes, connexin gene, endothelial nitric oxide synthase gene, and interleukin-10 gene. We look forward to the complete elucidation of genetic loci for common AF, which is now possible by using genomewide scans.