The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin

• Published in: Clinical, cosmetic and investigational dermatology Vol. 11; pp. 141 - 148
• Main Authors: Takagi, Yutaka, Ning, Xuanhe, Takahashi, Akihiko, Ishizaki, Chiaki, Nishizaka, Takahiro, Kaizu, Kazuhiro, Miyaki, Masahiro, Yamamuro, Hotaka, Kawashima, Makoto
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Atopic dermatitis; Clinical trials; Dermatitis; Dermatology; Eczema; Erythema; formulation; Humidity; inflammation; Itching; Medical treatment; moisturization; Original Research; Patients; scalp lotion; Seborrheic dermatitis; sensitive skin; Skin; Skin care; Skin diseases; Skin manifestations; Toiletries industry; Japan; formulation; scalp lotion; moisturization; sensitive skin; skin care; inflammation
• ISSN: 1178-7015; 1178-7015
• DOI: 10.2147/CCID.S158428

Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.
Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.
Skin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16
.
From these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.