Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage

Trauma is a leading cause of death worldwide with 5.8 million deaths occurring yearly. Almost 40% of trauma deaths are due to bleeding and occur in the first few hours after injury. Of the remaining severely injured patients up to 25% develop a dysregulated immune response leading to multiple organ...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 9; p. 891
Main Authors:	Aswani, Andrew, Manson, Joanna, Itagaki, Kiyoshi, Chiazza, Fausto, Collino, Massimo, Wupeng, Winston Liao, Chan, Tze Khee, Wong, W S Fred, Hauser, Carl J, Thiemermann, Chris, Brohi, Karim
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 08-05-2018
Subjects:	Adult Aged Alarmins - immunology Alarmins - metabolism Animals Cohort Studies damage-associated molecular patterns Disease Models, Animal DNA, Bacterial - blood DNA, Bacterial - immunology DNA, Mitochondrial - blood DNA, Mitochondrial - immunology Female Hexadimethrine Bromide - pharmacology Hexadimethrine Bromide - therapeutic use Humans Immunology Male Middle Aged Mitochondria - drug effects Mitochondria - immunology Mitochondria - metabolism Mitochondria - pathology mitochondrial DNA multiple organ dysfunction syndrome Multiple Organ Failure - drug therapy Multiple Organ Failure - immunology Multiple Organ Failure - mortality Multiple Organ Failure - pathology Multiple Trauma - drug therapy Multiple Trauma - immunology Multiple Trauma - mortality Multiple Trauma - pathology nucleic acid scavenger Prospective Studies Rats, Wistar Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - immunology Shock, Hemorrhagic - mortality Shock, Hemorrhagic - pathology trauma trauma hemorrhage Trauma Severity Indices Treatment Outcome Young Adult sterile inflammation trauma damage-associated molecular patterns mitochondrial DNA trauma hemorrhage nucleic acid scavenger multiple organ dysfunction syndrome Toll-like receptor-9
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