Biobased polyurethanes for biomedical applications

• Published in: Bioactive materials Vol. 6; no. 4; pp. 1083 - 1106
• Main Authors: Wendels, Sophie, Avérous, Luc
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01-04-2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Bioactive; Biobased; Biocompatibility; Biomedical; Polyurethanes; Scaffold; Tissue engineering; Biobased; Tissue engineering; Biocompatibility; Scaffold; Polyurethanes; Bioactive; Biomedical
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2020.10.002

Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.
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•Detailed last trends in biobased, biocompatible and biodegradable PUs.•A comprehensive study of “structure-biocompatibility relationships” on PU.•A rigorous analysis of biobased PUs as wound dressing materials.•The performances for short- and long-term implants were carefully analyzed.•An insight into the shape-memory materials for biomedical applications.