The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

The transcriptional repressor DREAM is involved in pain sensing. Tiruppathi and colleagues show that it is also involved in innate signaling by regulating the anti-inflammatory deubiquitinase A20. Here we found that the transcription repressor DREAM bound to the promoter of the gene encoding A20 to...

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Bibliographic Details
Published in:	Nature immunology Vol. 15; no. 3; pp. 239 - 247
Main Authors:	Tiruppathi, Chinnaswamy, Soni, Dheeraj, Wang, Dong-Mei, Xue, Jiaping, Singh, Vandana, Thippegowda, Prabhakar B, Cheppudira, Bopaiah P, Mishra, Rakesh K, DebRoy, Auditi, Qian, Zhijian, Bachmaier, Kurt, Zhao, You-Yang, Christman, John W, Vogel, Stephen M, Ma, Averil, Malik, Asrar B
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-03-2014 Nature Publishing Group
Subjects:	13 13/21 13/89 38 38/15 692/699 Acute Lung Injury - genetics Acute Lung Injury - metabolism Animals Biomedicine Chromatin Immunoprecipitation Cysteine Endopeptidases Disease Models, Animal DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Endotoxins Gene expression Gene Expression Regulation - immunology Genetic aspects Genetic research Immunoblotting Immunology Infectious Diseases Inflammation - genetics Inflammation - metabolism Intracellular Signaling Peptides and Proteins - biosynthesis Intracellular Signaling Peptides and Proteins - genetics Kv Channel-Interacting Proteins - metabolism Medical treatment Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - genetics NF-kappa B - metabolism Properties Real-Time Polymerase Chain Reaction Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcription factors Tumor Necrosis Factor alpha-Induced Protein 3 Ubiquitin-proteasome system Ubiquitin-Protein Ligases - biosynthesis Ubiquitin-Protein Ligases - genetics Upstream Stimulatory Factors - metabolism
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