NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin

Previous reports have shown that activation of N-methyl- d-aspartate (NMDA) receptors potentiates responses to activation of the group I metabotropic glutamate receptor mGluR5 by reversing PKC-mediated desensitization of this receptor. NMDA-induced reversal of mGluR5 desensitization is dependent on...

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Bibliographic Details
Published in:	Neuropharmacology Vol. 49; no. 1; pp. 135 - 145
Main Authors:	Alagarsamy, Sudar, Saugstad, Julie, Warren, Lee, Mansuy, Isabelle M., Gereau, Robert W., Conn, P. Jeffrey
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 2005
Subjects:	Animals Autoradiography - methods Brain - drug effects Brain - enzymology Calcineurin - metabolism Calcineurin - pharmacology CHO Cells - drug effects CHO Cells - enzymology Cricetinae Cricetulus Dose-Response Relationship, Drug Drug Synergism Electric Stimulation - methods Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Excitatory Amino Acid Agonists - pharmacology Glutamate Glutamic Acid - pharmacology Glutathione Transferase Hydroxylation - drug effects Immunoblotting - methods Immunoprecipitation - methods LTD LTP Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Potentials - radiation effects Metabotropic Methoxyhydroxyphenylglycol - analogs & derivatives Methoxyhydroxyphenylglycol - pharmacology Mutagenesis - physiology N-Methylaspartate - pharmacology Okadaic Acid - pharmacology Oocytes - drug effects Oocytes - enzymology Patch-Clamp Techniques - methods Phosphatidylinositols - metabolism PKC Plasticity Protein Kinase C - pharmacology Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Transfection Xenopus Metabotropic LTP PKC Glutamate LTD Plasticity
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