小鼠甲醇氧化应激的电子顺磁共振的研究

建立了小鼠甲醇中毒的氧化应激模型,研究了甲醇诱导小鼠产生氧化应激状态,探讨了大黄中草药和维生素C对小鼠甲醇氧化应激的保护作用.模型小鼠共分为5个组：空白组、对照组、甲醇应激组、大黄组、维生素C（Vc）组.利用电子自旋捕捉技术研究了小鼠甲醇氧化应激不同模型组小鼠体内的肝、肾、脾、心、肺和脑中产生的自由基强度的变化.结果表明：甲醇诱发了小鼠体内自由基的产生,甲醇组和生理盐水组相比,自由基的强度明显增强（显著性差异统计指标P＜0.01）;而大黄和Vc对小鼠甲醇氧化应激有保护作用,大黄组、Vc组和甲醇组相比自由基的强度则明显降低（P＜0.01）....

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Published in:	波谱学杂志 Vol. 30; no. 4; pp. 507 - 515
Main Author:	周丽芳朱翔赵红莉蓝闽波史新梅
Format:	Journal Article
Language:	Chinese
Published:	华东理工大学,分析测试中心,上海200237%华东理工大学,分析测试中心,上海200237 2013 华东理工大学,上海市功能性材料化学重点实验室,上海200237%华东理工大学,上海市功能性材料化学重点实验室,上海200237
Subjects:	小鼠氧化应激甲醇电子顺磁共振（EPR）自旋捕捉自由基自由基氧化应激 EPR 电子顺磁共振(EPR) methanol 小鼠甲醇 free radical spin trapping 自旋捕捉 mice oxidative stress
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Abstract	建立了小鼠甲醇中毒的氧化应激模型,研究了甲醇诱导小鼠产生氧化应激状态,探讨了大黄中草药和维生素C对小鼠甲醇氧化应激的保护作用.模型小鼠共分为5个组：空白组、对照组、甲醇应激组、大黄组、维生素C（Vc）组.利用电子自旋捕捉技术研究了小鼠甲醇氧化应激不同模型组小鼠体内的肝、肾、脾、心、肺和脑中产生的自由基强度的变化.结果表明：甲醇诱发了小鼠体内自由基的产生,甲醇组和生理盐水组相比,自由基的强度明显增强（显著性差异统计指标P＜0.01）;而大黄和Vc对小鼠甲醇氧化应激有保护作用,大黄组、Vc组和甲醇组相比自由基的强度则明显降低（P＜0.01）.
AbstractList	O657.61; 建立了小鼠甲醇中毒的氧化应激模型,研究了甲醇诱导小鼠产生氧化应激状态,探讨了大黄中草药和维生素C对小鼠甲醇氧化应激的保护作用.模型小鼠共分为5个组:空白组、对照组、甲醇应激组、大黄组、维生素C(Vc)组.利用电子自旋捕捉技术研究了小鼠甲醇氧化应激不同模型组小鼠体内的肝、肾、脾、心、肺和脑中产生的自由基强度的变化.结果表明:甲醇诱发了小鼠体内自由基的产生,甲醇组和生理盐水组相比,自由基的强度明显增强(显著性差异统计指标P＜0.01);而大黄和Vc对小鼠甲醇氧化应激有保护作用,大黄组、Vc组和甲醇组相比自由基的强度则明显降低(P＜0.01). 建立了小鼠甲醇中毒的氧化应激模型,研究了甲醇诱导小鼠产生氧化应激状态,探讨了大黄中草药和维生素C对小鼠甲醇氧化应激的保护作用.模型小鼠共分为5个组：空白组、对照组、甲醇应激组、大黄组、维生素C（Vc）组.利用电子自旋捕捉技术研究了小鼠甲醇氧化应激不同模型组小鼠体内的肝、肾、脾、心、肺和脑中产生的自由基强度的变化.结果表明：甲醇诱发了小鼠体内自由基的产生,甲醇组和生理盐水组相比,自由基的强度明显增强（显著性差异统计指标P＜0.01）;而大黄和Vc对小鼠甲醇氧化应激有保护作用,大黄组、Vc组和甲醇组相比自由基的强度则明显降低（P＜0.01）.
Author	周丽芳朱翔赵红莉蓝闽波史新梅
AuthorAffiliation	华东理工大学,上海市功能性材料化学重点实验室,上海200237 华东理工大学,分析测试中心,上海200237
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Author_FL	ZHU Xiang SHI Xin-mei ZHAO Hong-li ZHOU Li-fang LAN Min-bo
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DocumentTitleAlternate	Methanol-Induced Oxidative Stress in Mice Studied by Electron Paramagnetic Resonance
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Keywords	自由基氧化应激 EPR 电子顺磁共振(EPR) methanol 小鼠甲醇 free radical spin trapping 自旋捕捉 mice oxidative stress
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Notes	EPR; oxidative stress; spin trapping; mice; methanol; free radical ZHOULi-fang1, ZHU Xiang1, ZHAO Hong-li1, LAN Min bo1,2 , SHI Xin-mei2 （1. Shanghai Key Laboratory of Functional Materials Chemistry East China .University of Science and Technology, Shanghai 200237, China 2. Research Centre of Analysis and Test, East China University of Science and Technology Shanghai 200237, China） 42-1180/04 A mouse model of acute methanol poisoning was established to evaluate the protective effects of rhubarb and vitamin C （Vc） on methanol-induced oxidative stress in different organs.The mice used in the study were randomly divided into five group：blank group,control group,methanol group,rhubarb group and Vc group.EPR spin trapping technique was employed to study the intensity change of spin adducts induced by reactive oxygen species （ROS） free radicals generated in different organs of the mice.Compared with the control group,the animals in the methanol group showed significantly increased amount of ROS free radicals in the or
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SubjectTerms	小鼠氧化应激甲醇电子顺磁共振（EPR）自旋捕捉自由基
Title	小鼠甲醇氧化应激的电子顺磁共振的研究
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