Differential expression of retinoid receptors in the adult mouse central nervous system

• Published in: Neuroscience Vol. 89; no. 4; pp. 1291 - 1300
• Main Authors: Kreżel, W, Kastner, P, Chambon, P
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1999; Elsevier; Elsevier - International Brain Research Organization
• Subjects: Anatomy; Animals; Biochemistry, Molecular Biology; Biological and medical sciences; Brain - cytology; Brain - metabolism; Central nervous system; CNS; Fundamental and applied biological sciences. Psychology; immunohistochemistry; Immunohistochemistry - methods; in situ hybridization; Life Sciences; Male; Mice; Mice, Inbred C57BL; RAR; Receptors, Retinoic Acid - genetics; Receptors, Retinoic Acid - metabolism; Retinoic Acid Receptor alpha; Retinoic Acid Receptor gamma; retinoid receptors; Retinoid X Receptors; RNA, Messenger - genetics; RXR; Spinal Cord - cytology; Spinal Cord - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic; Vertebrates: nervous system and sense organs; RAR; D 2R, dopamine 2 receptor; PPARs, peroxisomal proliferator-activated receptors; RBP, retinol binding protein; RXR, retinoid X receptor; CNS; TRs, thyroid hormone receptors; VDR, vitamin D 3 receptor; VAD, vitamin A deficiency; RXR; PNS, peripheral nervous system; MOB, main olfactory bulb; retinoid receptors; RAR, retinoic acid receptor; immunohistochemistry; ISH, in situ hybridization; RA, retinoic acid; in situ hybridization; Vertebrata; Mammalia; Mouse; Immunocytochemistry; Rodentia; Retinoid; Central nervous system; Gene expression; Biological receptor
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/S0306-4522(98)00342-X

The immunocytochemical distribution of retinoid receptors has been analysed in the mouse adult central nervous system. All retinoic acid receptors (
α,
β and
γ) and retinoid X receptors (
α,
β and
γ) were detected and found to exhibit specific patterns of expression in various areas of the telencephalon, diencephalon and rhombencephalon. The protein localization of several retinoic acid receptors and retinoid X receptors did not correlate with the distribution of the corresponding RNA transcripts, as studied by
in situ hybridization and RNase protection assays.
This suggests that the expression of retinoid receptors could be post-transcriptionally regulated, which may contribute to their specific localization in the adult nervous system.